25,481 Michigan Sepsis Patients Just Provided the Clearest Observational Evidence Yet That the 30 mL/kg Fluid Mandate Should Bend to Individual Comorbidity

The June 2026 JAMA Network Open cohort study from the Michigan Hospital Medicine Safety Consortium, senior-authored by Hallie Prescott, analyzed weight-based fluid resuscitation across 67 hospitals and four clinical subgroups defined by hypoperfusion severity and comorbidity burden.