Why Mast Cells Wake You Between 2 and 4am

And why antihistamines only get you part of the way there. If you have MCAS, you know the pattern before I finish describing it. You wake somewhere between 2 and 4am. Not groggy - alert. Heart going. Skin flushed, or itching, or just a whole-body sense of alarm with nothing to attach it to. You were asleep, and then you were completely awake, and there was no in-between. Almost everything written…