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A straightforward look at the day's top news in 20 minutes. Powered by ABC News. Hosted by Brad Mielke.

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Could mRNA Give Us a Cancer Vaccine?

Drugmakers Merck and Moderna unveil a study claiming an experimental mRNA vaccine reduced recurrence of melanoma. Progressive Democrats surprise analysts with primary wins in Florida. And a former Ukrainian defense minister says Volodymyr Zelenskyy should face a wartime election. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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That’s So Meta: Landmark Tech Trial Begins

Attorneys give opening statements in a landmark case taking on Meta’s policies for young users. Shipping traffic slows in the Middle East, worrying economists worldwide. And Pennsylvania authorities charge 14 people in connection with an alleged cocaine trafficking ring at Penn State. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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What We Know About Hayden Panettiere’s Death

Actress Hayden Panettiere is found dead at the age of 36. Family members take the stand in defense of Lindsay Clancy. And an ABC News analysis shows military recruitment has become more successful, though not necessarily for the reasons given by Defense Sec. Pete Hegseth. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Ukraine Just Launched Its Biggest Attack of the War

Ukraine launches a massive drone attack against targets near Russia’s capital. Flooding turns deadly in Indianapolis. And with students about to report to class, “dorm designers” are charging thousands of dollars for custom interiors. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Breaking: Mangione Pleads Guilty in Federal Court

Luigi Mangione has just pleaded guilty to two federal charges. ABC’s Kyra Phillips reports. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Luigi Mangione Expected to Plead Guilty: Sources

Sources say Luigi Mangione is expected to make a guilty plea in court Friday, but it’s unclear what that might entail. Military families and lawmakers raise concerns over reports of sailors going overboard off the USS Lincoln. And Flock makes changes to its surveillance network policy. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Lessons from Wisconsin’s Primary Surprise

A win by moderate Democrat David Crowley in the Wisconsin governor’s race prompts questions for the left wing of the party. A hearing in federal court suggests a potential plea deal for Luigi Mangione. And an ICE contract is set to deliver millions of dollars’ worth of gloves that can deliver an electric shock. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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President Trump’s Secret Flight

Washington is stunned by reports that President Trump secretly switched flights in the face of an Iranian threat. Colombian volunteers dig through rubble for earthquake survivors. And ahead of a new inflation report, Americans’ credit card debt hits $1.25 trillion. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Scores Killed in Colombia Quake

A 7.4 magnitude earthquake in Colombia has killed at least 100 and counting. President Trump issues an executive order aiming to reduce the number of vaccines given to infants. And the Democratic establishment tries to find an alternative to Democratic Socialist Francesca Hong in tonight’s Wisconsin primary. AP Photo/Santiago Saldarriaga Learn more about your ad choices. Visit…

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Ceasefire 2.0: Iran Issues Tough Demands

As President Trump teases diplomatic advancements, Iran makes demands beyond the terms of the first ceasefire. Puerto Rico begins rationing water to residents as reservoirs run low. And a trial begins over the thirty-year-old murder of Tupac Shakur. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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Concerns Raised Over US Missile Stockpile

The White House responds after reports of significantly depleted U.S. stocks of air defense missiles. Senate Democrats target the Pentagon after it changed how it accounts for casualties in the ongoing war with Iran. And the FDA approves Moderna's new mRNA flu vaccine. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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What Progressive Primary Wins Mean for November

Michigan Senate race takes shape after key Democratic primary. Trump doesn't rule out firing Jeanine Pirro after charges were dropped against three-time Olympian and alleged Reflecting Pool vandal. And CDC data shows cases of a potentially deadly fungus detected in 27 states. AP Photo/Julia Demaree Nikhinson Learn more about your ad choices. Visit podcastchoices.com/adchoices

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