St. John’s Wort. Tincture of the whole plant.
Hypericum is indicated for LACERATED, injured, or inflamed nerves.
Injury to, or reflected from, the brain or spinal cord.
Very painful injuries to nerve-rich parts i.e., teeth, tongue, coccyx, eyes, finger tips, genitals.
Intolerably violent, shooting, lancinating pains along the nerves; radiating pains, with crawling and numbness. Neuritis following injury. Neuralgia of the stump. Shuddering. Spasms. Tetanus. Heaviness or formication in the brain.
Affinity for: SPINAL NERVES. COCCYX. Bites. Fright. Shock. Wounds.
Worse(<): INJURY. JAR. Concussion. Penetrating / puncture wounds. Shock. Bruises. Exertion. Touch. Change of / foggy weather. Cold. Damp. Motion.1
Recent double blind randomized placebo-controlled trials including Hypericum have found significant reduction in:
pain and swelling linked to odontogenic (tooth) infections2
chronic low-back pain 3
analgesic consumption in post operative pain patients4
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A case report describes a female with a history of trigeminal neuralgia (TN). Unable to get an appointment, this woman discovered Hypericum perforatum via the internet. The dramatic response to an over-the-counter Hypericum perforatum homeopathic medicine is outlined by orofacial pain clinicians.5
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Contrary to the widely held view that a homeopathic medicine (above 12C and Avogadro’s limit) contains no trace of its original ‘source’ substance, Hypericum based research demonstrates that micro and nanoscale particles are contained in all potencies, including ultra-high dilutions of 30C→50M.6
This Materia Medica portrait is shared by the Australasian College of Homeopathy featured as part of a Special Presentation by Hpathy, June 2026.
‘In contrast to frequent claims, the available Meta Analyses of homoeopathy in placebo-controlled randomised trials for any indication show significant positive effects beyond placebo. Compared to other medical interventions, the quality of evidence for efficacy of homoeopathy was similar or higher than for 90% of interventions across medicine. Accordingly, the efficacy evidence from placebo-controlled randomised trials provides no justification for regulatory or political actions against homoeopathy in health-care systems.’7
Sarah Penrose has studied and practiced homeopathy since 2005. Alongside three qualifications in homeopathy, Sarah is currently completing a Master of Applied Health Science research thesis which aims to advance understanding of homeopathic medicine. As of 2026, Sarah is principal of the Australasian College of Homeopathy collegehom.com
Boger, C.M. (2002). A Synoptic Key of the Materia Medica: A Treatise for Homeopathic Students. Hypericum. Rearranged and Augmented Edition. B. Jain Publishers. (Originally published 1915).
Sasmal, S., Dey, S., Ghosh, S., et al. (2025). Efficacy of Individualized Homeopathic Treatment in Uncomplicated Odontogenic Infections: A Randomized, Double-blind, Placebo-controlled Clinical Trial. Alternative therapies in health and medicine, AT11729. Advance online publication. PMID: 40862849
Muduli, S., Sarkar, S., Pal, R., et al. (2025). Homeopathic Treatment of Chronic Low-Back Pain: A Double-Blind, Randomized, Placebo-Controlled Trial. Journal of integrative and complementary medicine, 31(6), 565–576. doi.org/10.1089/jicm.2024.0564
Raak, C., Scharbrodt, W., Berger, B., et al. (2022). Hypericum perforatum to Improve Postoperative Pain Outcome After Monosegmental Spinal Sequestrectomy (HYPOS): Results of a Randomized, Double-Blind, Placebo-Controlled Trial. Journal of integrative and complementary medicine, 28(5), 407–417. doi.org/10.1089/jicm.2021.0389
Assiri, K., Alyami, Y., Uyanik, J. M., & Romero-Reyes, M. (2017). Hypericum perforatum (St. John’s Wort) as a possible therapeutic alternative for the management of trigeminal neuralgia (TN) - A case report. Complementary therapies in medicine, 30, 36–39. https://doi.org/10.1016/j.ctim.2016.10.014
Kalliantas, D., Kallianta, M., Kordatos, K., et al. (2021). Micro-nano particulate compositions of Hypericum perforatum L in ultra high diluted succussed solution medicinal products. Heliyon, 7(4), e06604. doi.org/10.1016/j.heliyon.2021.e06604
Hamre, HJ., Glockmann, A., von Ammon, K et al. (2023). Efficacy of homoeopathic treatment: Systematic review of meta-analyses of randomised placebo-controlled homoeopathy trials for any indication. Systematic Rev. Oct 7;12(1):191. doi.org/10.1186/s13643-023-02313-2
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