The first issue of The Medical-Surgical Journal , the oldest biomedical scientific journal in Romania, appeared in January 1887. Its appearance and evolution were the result of the foundation, in 1833, of the Society of Physicians and Naturalists , the first scientific society in the Romania Principalities, and later on by the development of higher medical education, the Iasi Faculty of Medicine (1879), which since 1990 has become the “Grigore T. Popa” University of Medicine and Pharmacy from…
Peripheral artery disease (PAD) progressing to chronic limb-threatening ischemia (CLTI) is associated with high morbidity and limb loss. Diabetes mellitus (DM) significantly influences disease distribution and clinical outcomes. The Bollinger score, GLASS classification, and WIfI staging are complementary tools for assessing anatomical burden and limb threat. This study aimed to analyze the…
Dental caries remains one of the most common oral diseases, with a multifactorial etiology involving biological, behavioral, socio-economic, and age-related factors. In elderly patients, physiological changes, systemic diseases, polypharmacy, reduced salivary flow, and gingival recession increase susceptibility to root caries. The aim of this study was to evaluate the prevalence of coronal and…
This study aims to compare the quality of root canal obturation achieved using different obturation techniques and to evaluate the adaptation of the interface between epoxy resin- based sealants and gutta-percha to the dentin walls of the root canal. Materials and methods: Thirty-six extracted single-rooted human teeth were used, prepared according to a standardized protocol and filled with…
The aim of this study was to characterize the nanoscale surface topography of a three-dimensional porcine collagen matrix under hydrated conditions, simulating a physiologically relevant environment. Materials and methods: Atomic force microscopy (AFM) was performed in hydrated conditions to evaluate surface topography, deflection signal, three-dimensional reconstruction, surface profile, and…
Financial well-being is a multidimensional construct that reflects perceived financial control and security. While it is not directly measured in this study, money attitudes represent an important cognitive-affective component associated with financial well-being. Materials and methods: This cross-sectional study examined the relationship between personality traits and money attitude dimensions…
Population aging presents growing challenges for maintaining quality of life in later adulthood. Conservative personal values and existential meaning are both associated with well-being in older adults, yet their functional relationship remains unclear. Aim: The present study aimed to investigate the mediating mechanism through which the presence of meaning in life influences the relationship…
Craniopharyngiomas (CPs) are rare benign epithelial tumors of the sellar-suprasellar region that remain surgically challenging. Aim : To evaluate the clinical, imaging, pathological and surgical aspects of CPs diagnosed in adult patients as such previous analyses are rare. Materials and methods: We performed a retrospective study that included adult patients (≥18 years) with surgical treated and…
Osteoporosis is a major public health problem characterized by reduced bone mass and increased fracture risk. Lifestyle factors play an important role in its development and prevention. This study examines the relationship between lifestyle factors and osteoporosis in an adult Romanian population, providing recommendations for prevention through adequate calcium and vitamin D intake and the…
Pepsin, a component of gastric refluxate, has been investigated as a potential salivary biomarker for gastro-esophageal reflux disease (GERD), although its diagnostic accuracy remains uncertain. This proof-of-concept study aimed to characterize the effects of pepsin on the human salivary peptidome using matrix-assisted laser desorption/ionization-time of flight (MALDI-ToF) mass spectrometry.…
Chitosan-based nanofibers can serve as carriers for antimicrobial agents, providing controlled drug release and biocompatibility, which are crucial for tissue integration and healing. This study aimed to evaluate the in vivo biocompatibility of norfloxacin-loaded chitosan nanofibers (NorC) and norfloxacin-loaded chitosan nanofibers functionalized with boronic aldehyde (NorCB), in comparison with…
