Measles Vaccine Boosters For Senior Coming

Robert Malone had a very informative article about Measles and Boosters.

https://substack.com/app-link/post?publication_id=583200&post_id=211929605

I have written a bit about this myself

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March 9, 2025

So Measles has been in the news for a bit. I tried to tune it out with so much going on but I was just reviewing an old post of mine and decided to weigh in and bump it

First, lets get to the current outbreak

The United States has now confirmed 2,566 measles cases in 2026, exceeding the 2,289 recorded in all of 2025 and standing as the highest annual count since 1991 (CDC 2026a). No one has died. Three deaths across 2,289 cases in 2025 works out near 1.3 per thousand, which predicts roughly three deaths this year, and observing zero carries a probability near four percent under a simple Poisson assumption. The hospitalization rate moved further and more convincingly, from eleven percent to seven percent (CDC 2026a)

Remember, Malone here is talking about Case Fatality Rate (CFR). But as he explains in the post the deaths were due to poorly treated bacterial pneumonia which is how measles usually kills. The Doctors screwed up. Back in 1963 out of 4 million estimated measles infections, only 10% were diagnosed as such by a doctor (cases) with 400 deaths. Case Fatality Rate (CFR) 1/1000, Infection Fatality Rate (IFR), 1/10,000. Before antibiotics, measles killed many children

Malone goes on to discuss the immunology and durability of immunity behind natural Measles infection and Vaccine induced Immunity. Natural infection is lifelong, while Vaccine Immunity is probably not lifelong. The uncertainty is because the oldest of those with Vaccine Only Immunity are only in their 60’s, while those Vaccinated as children according to the latest CDC recommendations (2 doses) are not yet 40 years old.

Its the older Vaccine Immunity group that is of most concern because while Measles is a relatively mild childhood disease it is a much more serious disease in adults, and can be expected to be much more serious in older adults .

We have wiped out our natural boosters which were measles outbreaks in children, and vaccine boosters in older adults either don’t work or only provide a temporary boost , meaning annual boosters might be needed with the current live attenuated virus vaccine.

Malone zeros in on a cohort deserving attention

Children vaccinated between 1963 and 1967 were born between 1953 and 1966. Those born before 1957 are presumed immune from natural infection anyway, which leaves a birth cohort of 1957 to 1966. In 2026, they are approximately sixty to seventy years old.

ACIP has recommended revaccinating this group for decades. Anyone who received killed measles vaccine, or measles vaccine of unknown type, between 1963 and 1967 should be considered unvaccinated and given at least one dose of live attenuated vaccine (CDC 2026c)

The current vaccine cannot generate the bone marrow plasma cell population that wild infection generates, and repetition cannot make it do so, because pre-existing antibody neutralizes each subsequent dose before it can replicate.

A better product would have to clear a specific bar. It must seed durable plasma cell memory without inflicting the lymphocyte depletion and memory loss that produce that durability in natural infection. It must remain immunogenic in the presence of residual antibody, which a replication-dependent platform cannot do by definition.

A non-replicating platform sidesteps that problem. Because it does not need to multiply, neutralization of the inoculum does not defeat it. Deliver enough antigen in the dose itself, with an adjuvant to drive germinal center activity, and you can immunize someone who already carries antibody. Candidate approaches include adjuvanted subunit protein directed at the two measles surface glycoproteins, viral vectors, and nucleic acid platforms.

I bet Moderna is working on a mRNA vaccine right now.

I think Malone is wrong to focus on this group. The main reason is few born from 1957-1961 actually got any vaccine and were exposed to natural measles outbreaks and probably had measles and have natural immunity. Few of us in this group have vaccine cards to refer to so any presumption presuming only vaccine immunity would be faulty.

So I asked Grok

Likelihood for someone born 1957–1960 of being vaccinated between 1963 and 1967:** Moderately low to moderate, and substantially lower than for younger cohorts, because many already had natural immunity and campaigns prioritized younger children.

- Born 1957: ages ~6–10 during 1963–1967.

- Born 1960: ages ~3–7 during that period.

These children were in the preschool-to-early-elementary range when vaccine became available. By age 5–10 in the pre-vaccine era, a large and rising share had already had measles (1965 survey data showed history of measles rising with age—e.g., roughly 30–50%+ by ages 4–7 and higher thereafter). United States Immunization Survey (USIS) data from September 1965 showed measles vaccine history of about 33% among ages 1–4 [born 1961-1964] and only ~19% among ages 5–9 [born 1956-1960] Coverage among 1- to 4-year-olds rose over the period (roughly 24% in 1964, 33% in 1965, 45% in 1966, and ~56% in 1967), but remained well below modern levels and was lower for older kids in the relevant age bands.

Its very likely that some of those who were vaxxed had sub-clinical infection with the natural virus before being vaccinated

That said, there will likely come a time when outbreaks begin in vaccinated people as they age. Perhaps their residual immunity while not preventing infection will limit the severity of disease. You can be sure they will exaggerate the risk.

One interesting thing Malone brought up that I had previously discussed was the immune amnesia caused by Measles Infection. This is because measles virus latches onto receptors of T-Cells and B-Cells including all important memory cells.

While I don’t think this is something that worrisome with children given they are able to acquire new immunity (perhaps by revaccination). It could be problematic if it wiped out memory in older adults as their immune systems are already suppressed and they don’t respond as well to vaccination or infection. Of course, we don’t know if this will be a problem, but they will tell us with certainty it will.

Cha-Ching! $$$

End