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PainSci Updates · Aug 12, 2026

Melatonin is not a painkiller [1m]

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Melatonin could plausibly help people with chronic musculoskeletal pain, presumably by improving sleep . Unfortunately, a new review of 23 trials ( Wu ) shows that it doesn’t get the job done. It might improve their sleep slightly, but that does not appear to translate into pain relief. The headline result is honest: no better than placebo. And you should probably look no further, because the…

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