AI-designed intrabodies could help target disease-linked proteins inside cells, with potential applications in Parkinson's, MND and Alzheimer's treatments. The microscopic antibody fragments are designed to remain stable inside human cells, where they can attach to proteins associated with neurodegenerative conditions. Researchers used artificial intelligence and protein redesign techniques to…
Severe mental illness is linked to higher stroke risk in early and middle adulthood and increased dementia risk across adulthood, a study suggests. An analysis of health records from nearly 700,000 people found significant associations between severe mental illness and both dementia and stroke. The link with dementia was seen across every age group studied, [...]
TBI prevention may depend as much on roads, emergency access and local risks as hospital care, a global study suggests. Researchers examining traumatic brain injury across 29 countries found motor vehicle crashes were the largest single cause globally, although patterns varied substantially between countries. In wealthier countries, for example, ground-level falls accounted for high rates [...]
By Rowan Morgan-Ruffley Rehabilitation does not stop when a therapy session ends. For someone rebuilding their life following a brain injury, stroke, spinal cord injury, amputation or other complex condition, much of the real work of rehabilitation happens at home and in the community. It happens when someone tries to prepare a meal, get back [...]
A community of people living with spinal cord injuries, their families and supporters will come together this September to raise £25,000 for specialist rehabilitation through Neurokinex’s annual Step Up Challenge. The fundraising challenge will see the Neurokinex community unite to help ensure newly injured people can access rehabilitation and support at a time when it [...]
Targeted blood pressure control may reduce repeat stroke risk after intracerebral haemorrhage, a meta-analysis of nearly 3,000 patients suggests. Intracerebral haemorrhage, or ICH, is a type of haemorrhagic stroke caused by bleeding within the brain. Patients receiving intensive blood pressure-lowering treatment had a 38 per cent lower risk of recurrent stroke than those receiving less [...]
A flexible device may help restore multiple functions after spinal cord injury by interpreting signals linked to movement, sensation and organs. The device wraps around the spinal cord and can interpret several types of signals at once. Preclinical studies found the device could accurately detect signals associated with intended movement, distinguish sensory information and identify [...]
A stroke drug may help preserve and repair myelin damaged by multiple sclerosis, according to a review of animal studies. Nimodipine was also linked to reduced inflammation, nerve damage and disease severity in several of the studies reviewed. Myelin is the protective coating around nerve fibres that is damaged in multiple sclerosis, or MS, disrupting [...]
By Natalie Mackenzie, BIS Services A few years ago, I wrote a book. Not the kind you curl up with, but the kind that sits on a rehab shelf, or in a therapy room, and helps someone make sense of one of the most misunderstood parts of life after brain injury: fatigue. Those working in [...]
Tai Chi may improve motor symptoms, physical function and quality of life in people with early to mid-stage Parkinson's, a small trial suggests. A 14-week programme combining resistance and stretching exercises led to similar overall improvements in motor symptoms, although the two approaches appeared to have different physical benefits. Tai Chi appeared to have relatively [...]
By Spinal Injuries Association with R.F.Hunt In 2006, Arshad (Ash) Mahmood (54) from Bradford was diagnosed with Cauda Equina Syndrome, a compression of the nerves in the lower spine. After emergency surgery, Ash’s right leg was still numb below the knee and he was experiencing nerve pain, but he could walk using crutches. However, in [...]