2,4,Dinitrophenol Aka MP-101

Known as DNP (Don’t be stupid this is a dangerous drug)

This drug is lethal, because it has a long half life, and because results build up instead of being immediate. Basic mechanism is to uncouple mitochondria. This generates a lot of waste heat but also increases ATP production of mitochondria. Lethal action is death by internal cooking, and effect is powerful enough that ice baths and such will not help. If you overdose hospital cannot do anything but hold your hand as you die a painful and horrible death. Follow cautious dosing schedule except to underdose.

Safe dose 1-4mg/kg (Lowest lethal ever recorded was 4.3g/kg but more typically above 6g/kg)

36 hour half life, so it sticks around for a while - you need to avoid building up to more than 4mg/kg too.

Take with plenty of water, electrolytes, and VitaC. Electrolytes are to support mitochondria function and replace losses due to sweating. (The body only eliminates this via sweating, so I would make sure some sweating happens if you use low doses. If you use moderate to higher safe doses, a lot of sweating will occur.) VitaC is to counter the tons of antioxidants that uncoupled mitochondria throw which causes bad side effects such as temporary blindness. Other antioxidants could work in this role, C is just cheap and easily absorbed.

Your body can develop tolerances, so washout periods and such may be a good idea. Don’t get complacent with second or third round of using this drug, start out dosing very small and build up slowly. Monitoring core body temperature may be a way of gauging the effectiveness of the drug, with a goal of raising it to 98.6. Again be aware it takes a while for the effect to develop and the drug to dissipate so don’t up doses if the body temperature is not raised as quickly as you’d like.

The plus side is that it appears mitochondria stay somewhat uncoupled after use, and a round of this drug may actually lower the body’s weight set point. Hopefully you won’t just put all the weight back on.

MP-101 is a rebrand of this drug in studies, at less than 1/10th the dosage.

Dose used for MP-101 study. .1mg/kg

From STUDY: helps w/ multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Huntington Diasease (HD), Alzheimer Disease (AD), mental illness, obesity, diabetes, immunodeficiency, congenital disorders.

Primary Source: Lost Knowledge: Obesity - by Adam Gaertner - veryvirology

“SAFER” alternatives:

High does aspiring is also a mitochondria uncopuler. 1 gram aspirin + .5g every 4-6 hours. W/ kaffa (or 1 gram theobromine, lower toxicity at 1g/kg) aspiring can be reduced to .8 gram initial and .4g every 5 hours. Add ephedra to complete the bodybuilders (ECA stack). This is different though, as the stimulants are supporting aspirin instead of the other way around. VitaK is used to counter the bleeding risk of so much aspirin. I’m not sure K really increases clotting factor if you aren’t deficient in K. Caution: Ephedra stresses the heart, and high caffeine does too. Aspirin has a bleeding risk (ulcers shouldn’t be a problem if you don’t have h. pylori) and potentially bad interactions with fever.

3,5 Diiodo-L-Thyronine (T2)

Thyroid. Some T4, but mostly constant small doses of T3. If supporting nutrition and &c. is not in place T3 will convert to reverse T3 which will give the opposite of the intended effect. Really have to dive into the Ray Peating community for this, and they may give you a list 20 supplements long to make thyroid work.

clenbuterol, tren. Tren is anti-cortisol.

MOTS-C - perhaps actually increases directed energy production instead of increasing energy production via a leak.