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Digital garden with notes about whatever I find interesting and think about

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Unique in the shopping mall: On the reidentifiability of credit card metadata

{'id': 'montjoye2015', 'abstract': 'Large-scale data sets of human behavior have the potential to fundamentally transform the way we fight diseases, design cities, or perform research. Metadata, however, contain sensitive information. Understanding the privacy of these data sets is key to their broad use and, ultimately, their impact. We study 3 months of credit card records for 1.1 million people…

Neutron tomography of Van Leeuwenhoek’s microscopes

{'id': 'cocquyt2021', 'abstract': 'The technique of neutron tomography has, after 350 years, enabled a first look inside the iconic single-lens microscopes of Antoni van Leeuwenhoek. Van Leeuwenhoek’s 17th-century discovery of “animalcules” marks the birth of microbiology. His skillfully self-produced microscope lenses remained unsurpassed for over 150 years. Neutron tomography now enabled us to…

Chankillo: A 2300-Year-Old Solar Observatory in Coastal Peru

{'id': 'ghezzi2007', 'abstract': ' The Thirteen Towers of Chankillo run north to south along a low ridge within a fourth-century B.C.E. ceremonial complex in north coastal Peru. From evident observing points within the adjacent buildings to the west and east, they formed an artificial toothed horizon that spanned—almost exactly—the annual rising and setting arcs of the Sun. The Chankillo towers…

The mustatils: cult and monumentality in Neolithic north-western Arabia

{'id': 'thomas2021', 'abstract': ', \nNorth-western Arabia is marked by thousands of prehistoric stone structures. Of these, the monumental, rectilinear type known as mustatils has received only limited attention. Recent fieldwork in AlUla and Khaybar Counties, Saudi Arabia, demonstrates that these monuments are architecturally more complex than previously supposed, featuring chambers,…

Astronomical aspects of Group E-type complexes and implications for understanding ancient Maya architecture and urban planning

{'id': 'sprajc2021', 'abstract': 'In the 1920s, during the first archaeological excavations at Uaxactún, Petén, Guatemala, an architectural complex named Group E was interpreted as an ancient Maya astronomical observatory, intended specifically for sighting the equinoctial and solstitial sunrises. In the following decades, a large number of architectural compounds with the same configuration have…

A surge of light at the birth of a supernova

{'id': 'bersten2018', 'abstract': 'The discovery of a newly born type IIb supernova reveals a rapid brightening at optical wavelengths that corresponds to the shock-breakout phase of the explosion.', 'accessed': {'date-parts': [['2021', 5, 13]]}, 'author': [{'family': 'Bersten', 'given': 'M. C.'}, {'family': 'Folatelli', 'given': 'G.'}, {'family': 'García', 'given': 'F.'}, {'family': 'Van Dyk',…

Engagement in science through citizen science: Moving beyond data collection

{'id': 'phillips2019', 'abstract': 'To date, most studies of citizen science engagement focus on quantifiable measures related to the contribution of data or other output measures. Few studies have attempted to qualitatively characterize citizen science engagement across multiple projects and from the perspective of the participants. Building on pertinent literature and sociocultural learning…

The Archaeo-Ethnology of Hunter-Gatherers or the Tyranny of the Ethnographic Record in Archaeology

{'id': 'wobst1978', 'abstract': 'Many of the constructs of space, time and behavior in the ethnographic literature on hunter-gatherers may be partly determined by the severe constraints on ethnographic fieldwork. This paper discusses the genesis of some of these constructs, points out that the anthropological theory consumed by archaeologists is often based on, or developed for these constructs,…

Gender and the Hunter-Gatherer Archaeological Record: A View from the Thukela Basin

{'id': 'mazel1992', 'abstract': "In this paper I argue that it is imperative for archaeologists to incorporate a gender focus in their research. Coupled with this however, must be the notion that both women and men were active participants in the making of history. It is submitted that adopting this approach will enable archaeologists to develop a deeper understanding of human history. I then…

Reconstruction of ancient microbial genomes from the human gut

{'id': 'wibowo2021', 'abstract': 'Loss of gut microbial diversity1–6 in industrial populations is associated with chronic diseases7, underscoring the importance of studying our ancestral gut microbiome. However, relatively little is known about the composition of pre-industrial gut microbiomes. Here we performed a large-scale de novo assembly of microbial genomes from palaeofaeces. From eight…

Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression

{'id': 'eiberg2008', 'abstract': 'The human eye color is a quantitative trait displaying multifactorial inheritance. Several studies have shown that the OCA2 locus is the major contributor to the human eye color variation. By linkage analysis of a large Danish family, we finemapped the blue eye color locus to a 166\xa0Kbp region within the HERC2 gene. By association analyses, we identified two…

Adding is favoured over subtracting in problem solving

{'id': 'meyvis2021', 'abstract': 'People tend to solve problems by adding features.', 'accessed': {'date-parts': [['2021', 5, 2]]}, 'author': [{'family': 'Meyvis', 'given': 'Tom'}, {'family': 'Yoon', 'given': 'Heeyoung'}], 'citation-key': 'meyvis2021', 'container-title': 'Nature', 'DOI': '10.1038/d41586-021-00592-0', 'issue': '7853', 'issued': {'date-parts': [['2021', 4]]}, 'language': 'en',…

A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

{'id': 'adhikari2016', 'abstract': 'We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial hair (beard thickness, monobrow, eyebrow thickness). We found 18 signals of association reaching genome-wide significance (P values 5 × 10−8 to 3 × 10−119), including 10 novel associations. These include novel loci for…

Origins and evolution of extreme life span in Pacific Ocean rockfishes

{'id': 'kolora2021', 'accessed': {'date-parts': [['2021', 11, 27]]}, 'author': [{'family': 'Kolora', 'given': 'Sree Rohit Raj'}, {'family': 'Owens', 'given': 'Gregory L.'}, {'family': 'Vazquez', 'given': 'Juan Manuel'}, {'family': 'Stubbs', 'given': 'Alexander'}, {'family': 'Chatla', 'given': 'Kamalakar'}, {'family': 'Jainese', 'given': 'Conner'}, {'family': 'Seeto', 'given': 'Katelin'},…

Quantification of protein interactions and solution transport using high-density GMR sensor arrays

{'id': 'gaster2011', 'abstract': 'Monitoring the kinetics of protein interactions on a high-density sensor array is vital to drug development and proteomic analysis. Label-free kinetic assays based on surface plasmon resonance are the current gold standard, but they have poor detection limits, suffer from non-specific binding, and are not amenable to high-throughput analyses. Here, we show that…

Validation of free flow electrophoresis as a novel plasma and serum processing and fractionation method in biobanking

{'id': 'gaillard2012', 'abstract': 'Free flow electrophoresis (FFE) is a fractionation method, based on isoelectric focusing (IEF). We validate the reproducibility of the method and show that it can be applied by biobanks in order to fractionate fluid biospecimens efficiently and reproducibly and to facilitate downstream proteomic applications. We also propose a simple method allowing researchers…

Parallel, linear, and subnanometric 3D tracking of microparticles with Stereo Darkfield Interferometry

{'id': 'rieu2021', 'abstract': 'While crucial for force spectroscopists and microbiologists, three-dimensional (3D) particle tracking suffers from either poor precision, complex calibration, or the need of expensive hardware, preventing its massive adoption. We introduce a new technique, based on a simple piece of cardboard inserted in the objective focal plane, that enables simple 3D tracking of…

Current advances and challenges in microfluidic free-flow electrophoresis—A critical review

{'id': 'novo2017', 'accessed': {'date-parts': [['2023', 1, 18]]}, 'author': [{'family': 'Novo', 'given': 'Pedro'}, {'family': 'Janasek', 'given': 'Dirk'}], 'citation-key': 'novo2017', 'container-title': 'Analytica Chimica Acta', 'container-title-short': 'Anal. Chim. Acta', 'DOI': '10.1016/j.aca.2017.08.017', 'ISSN': '00032670', 'issued': {'date-parts': [['2017', 10]]}, 'language': 'en', 'note':…

The music of life: biology beyond genes

{'id': 'noble2008', 'author': [{'family': 'Noble', 'given': 'Denis'}], 'citation-key': 'noble2008', 'ISBN': '978-0-19-922836-2', 'issued': {'date-parts': [['2008']]}, 'language': 'en', 'number-of-pages': '153', 'publisher': 'Oxford University Press', 'publisher-place': 'Oxford', 'source': 'K10plus ISBN', 'title': 'The music of life: biology beyond genes', 'title-short': 'The music of life',…

The five dysfunctions of a team: a leadership fable

{'id': 'lencioni2002', 'author': [{'family': 'Lencioni', 'given': 'Patrick'}], 'call-number': 'HD66 .L456 2002', 'citation-key': 'lencioni2002', 'edition': '1st ed', 'ISBN': '978-0-7879-6075-9', 'issued': {'date-parts': [['2002']]}, 'number-of-pages': '229', 'publisher': 'Jossey-Bass', 'publisher-place': 'San Francisco', 'source': 'Library of Congress ISBN', 'title': 'The five dysfunctions of a…

Interferometric nanoparticle tracking analysis enables label-free discrimination of extracellular vesicles from large lipoproteins

{'id': 'kashkanova2022a', 'abstract': 'Extracellular vesicles (EVs) are increasingly gaining interest as biomarkers and therapeutics. Accurate sizing and quantification of EVs remain problematic, given their nanometer size range and small scattering cross-sections. This is compounded by the fact that common EV isolation methods result in co-isolation of particles with comparable features.…

Refractive Index Matching: A General Method for Enhancing the Optical Clarity of a Hydrogel Matrix

{'id': 'franklin2002', 'accessed': {'date-parts': [['2023', 4, 1]]}, 'author': [{'family': 'Franklin', 'given': 'Jeffery'}, {'family': 'Wang', 'given': 'Zhi Yuan'}], 'citation-key': 'franklin2002', 'container-title': 'Chemistry of Materials', 'container-title-short': 'Chem. Mater.', 'DOI': '10.1021/cm025541x', 'ISSN': '0897-4756, 1520-5002', 'issue': '11', 'issued': {'date-parts': [['2002', 11,…

Characterization of nanoparticles-based vaccines for COVID-19

{'id': 'guerrini2022', 'abstract': 'Several vaccines against COVID-19 use nanoparticles to protect the antigen cargo (either proteins or nucleic acids), increase the immunogenicity and ultimately the efficacy. The characterization of these nanomedicines is challenging due to their intrinsic complexity and requires the use of multidisciplinary techniques and competencies. The accurate…

The Tiny Instrument Element

{'id': 'lelli2009', 'abstract': 'In the past few years, the idea of extending the Grid to cover also the remote access, control, management of instrument devices has been explored in a few initiatives. Existing tools lack in generality and require advanced specialized computer science knowledge, thus making them difficult to be broadly adopted in the scientific community. In this paper we present a…

High-speed interferometric spectrally encoded flow cytometry

{'id': 'golan2012', 'abstract': 'Spectrally encoded flow cytometry (SEFC) is a promising technique for noninvasive in vivo microscopy of blood cells. Here, we introduce a novel SEFC system for label-free confocal imaging of blood cells flowing at velocities of up to 10  mm/s within 65 μm-diameter vessels. The new system employs interferometric Fourier-domain detection and…

Diversity and Inclusion Efforts That Really Work

{'id': 'pedulla2020', 'abstract': 'A Stanford and Harvard professor convened a symposium on what’s actually working to improve diversity and inclusion in organizational life. In this article, David Pedulla summarizes the main findings. First, organizations should set goals, collect data, and hold people accountable for improving diversity within the organization. Second, organizations should…

Open hardware: From DIY trend to global transformation in access to laboratory equipment

{'id': 'wenzel2023', 'abstract': 'Open hardware solutions are increasingly being chosen by researchers as a strategy to improve access to technology for cutting-edge biology research. The use of DIY technology is already widespread, particularly in countries with limited access to science funding, and is catalyzing the development of open-source technologies. Beyond financial accessibility, open…

Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines

{'id': 'bansal2021', 'accessed': {'date-parts': [['2022', 6, 21]]}, 'author': [{'family': 'Bansal', 'given': 'Sandhya'}, {'family': 'Perincheri', 'given': 'Sudhir'}, {'family': 'Fleming', 'given': 'Timothy'}, {'family': 'Poulson', 'given': 'Christin'}, {'family': 'Tiffany', 'given': 'Brian'}, {'family': 'Bremner', 'given': 'Ross M.'}, {'family': 'Mohanakumar', 'given': 'Thalachallour'}],…

Acoustic force spectroscopy

{'id': 'sitters2015', 'abstract': 'Acoustic force spectroscopy applies acoustic forces across a large dynamic range for highly multiplexed single-molecule measurements in a simple, compact setup.', 'accessed': {'date-parts': [['2023', 10, 9]]}, 'author': [{'family': 'Sitters', 'given': 'Gerrit'}, {'family': 'Kamsma', 'given': 'Douwe'}, {'family': 'Thalhammer', 'given': 'Gregor'}, {'family':…

Identification of factors that contribute to recombinant AAV2 particle aggregation and methods to prevent its occurrence during vector purification and formulation

{'id': 'wright2005', 'author': [{'family': 'Wright', 'given': 'J Fraser'}], 'citation-key': 'wright2005', 'issue': '1', 'issued': {'date-parts': [['2005']]}, 'language': 'en', 'page': '8', 'source': 'Zotero', 'title': 'Identification of factors that contribute to recombinant AAV2 particle aggregation and methods to prevent its occurrence during vector purification and formulation', 'type':…

An Archaeological Perspective on the Andean Concept of <i>Camaquen</i> : Thinking Through Late Pre-Columbian <i>Ofrendas</i> and <i>Huacas</i>

{'id': 'bray2009', 'abstract': 'Ethnohistoric sources suggest that the indigenous inhabitants of Andean South America saw both people and things as animated or enlivened by a common vital force (\n camaquen\n ). In approaching the subject of\n camaquen\n archaeologically, I attempt to place objects and their materiality at the analytical centre, rather than the normally privileged ethnohistoric or…

Low-cost, fast prototyping method of fabrication of the microreactor devices in soda-lime glass

{'id': 'mazurczyk2008', 'abstract': 'In the context of biochips, the novel concept of a fast prototyping platform with application to surface chemistry studies is presented. Microreactors are fabricated in microscope glass slides, allowing for parallel screening. Both, the use of low-cost soda-lime glass and simplified, yet effective, method of masking render our approach affordable and…

Measure what matters: OKRs: the simple idea that drives 10x growth

{'id': 'doerr2018', 'abstract': "Part 1.OKRs in action --Google, meet OKRs : How OkRs came to Google, and the superpowers they convey --Father of OKRs: Andy Grove creates and inculcates a new way of structured goal setting --Operation crush : an Intel story : How OKRs won the microprocessor wars --Superpower #1: Focus and commit to priorities : OKRS help us choose what matters most --Focus : the…

NUMBERS DON&#39;T LIE.

{'id': 'smil2020', 'author': [{'family': 'SMIL', 'given': 'VACLAV'}], 'citation-key': 'smil2020', 'ISBN': '978-0-241-45442-8', 'issued': {'date-parts': [['2020']]}, 'language': 'en', 'note': 'OCLC: 1137806395', 'publisher': 'VIKING', 'publisher-place': 'Place of publication not identified', 'source': 'Open WorldCat', 'title': "NUMBERS DON'T LIE.", 'type': 'book'}

Application of microfluidic chip with integrated optics for electrophoretic separations of proteins

{'id': 'vieillard2007', 'abstract': 'This paper describes the fabrication, the characterization and the applications of a capillary electrophoresis microchip. This hybrid device (glass/PDMS) features channels and optical waveguides integrated in one common substrate. It can be used for electrophoretic separation and fluorimetric detection of molecules. The microfluidic performance of the device is…

A novel concept of the integrated fluorescence detection system and its application in a lab-on-a-chip microdevice

{'id': 'mazurczyk2006', 'abstract': 'In the paper, an innovative concept of fabrication of lab-on-a-chip (LOC) analytical microsystems, is presented. One of the major trends in design and fabrication of the LOC devices is integration of microfluidic separation part of the device with its detection optics. In our paper, we report a novel approach to this problem. As a substrate material for our LOC…

Payload distribution and capacity of mRNA lipid nanoparticles

{'id': 'li2022a', 'abstract': 'Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs, including payload distribution and capacity, which are critical to understanding structure-property-function relationships for further carrier development. Here, we report a method based on the…

Portable low-cost open-source wireless spectrophotometer for fast and reliable measurements

{'id': 'laganovska2020', 'abstract': 'We demonstrate a low-cost standalone portable spectrophotometer for fast and reliable measurement execution. The data acquired can be both displayed via a dedicated smartphone application or a computer interface, allowing users either to gather and view data on the move or set up a continuous experiment. All design and software files are open-source and are…

Science acceleration and accessibility with self-driving labs

{'id': 'canty2025', 'abstract': 'In the evolving landscape of scientific research, the complexity of global challenges demands innovative approaches to experimental planning and execution. Self-Driving Laboratories (SDLs) automate experimental tasks in chemical and materials sciences and the design and selection of experiments to optimize research processes and reduce material usage. This…

Flow cytometry in biotechnology

{'id': 'rieseberg2001', 'abstract': 'Flow cytometry is a general method for rapidly analyzing large numbers of cells individually using light-scattering, fluorescence, and absorbence measurements. The power of this method lies both in the wide range of cellular parameters that can be determined and in the ability to obtain information on how these parameters are distributed in the cell population.…

Why postdocs need entrepreneurship training

{'id': 'khan2023', 'accessed': {'date-parts': [['2023', 11, 22]]}, 'author': [{'family': 'Khan', 'given': 'Muhammad Shehryar'}, {'family': 'Casello', 'given': 'Jeffrey'}], 'citation-key': 'khan2023', 'container-title': 'Nature', 'DOI': '10.1038/d41586-023-03411-w', 'ISSN': '0028-0836, 1476-4687', 'issued': {'date-parts': [['2023', 11, 8]]}, 'language': 'en', 'note': '1 citations (Crossref)…

Multidimensional infrared diffusion-ordered spectroscopy in depletion mode distinguishes protein amyloids and monomers

{'id': 'giubertoni2023a', 'abstract': 'Conventional and two-dimensional infrared (2D-IR) spectroscopy are well suited to study amyloid aggregates, because the amide I mode is a sensitive probe of the aggregate structure. However, these methods are not so useful to study mixtures of aggregates and monomers, which generally have overlapping amide I spectra. Here, we show that IR-Diffusion-Ordered…

Precision size and refractive index analysis of weakly scattering nanoparticles in polydispersions

{'id': 'kashkanova2022', 'abstract': 'Characterization of the size and material properties of particles in liquid suspensions is in very high demand, for example, in the analysis of colloidal samples or of bodily fluids such as urine or blood plasma. However, existing methods are limited in their ability to decipher the constituents of realistic samples. Here we introduce iNTA as a new method that…

Academic entrepreneurship in life sciences: the case of a moderate innovator country

{'id': 'teixeira2016', 'abstract': 'The commercialization of research done by universities and research institutes is seen as a key element of entrepreneurship, justifying a better understanding of the entrepreneurial process within those institutions. Despite efforts in recent decades, there remains a widespread ignorance about who are the individuals with a greater vocation for research and…

Real-Time Nanoparticle Characterization Through Optofluidic Force Induction

{'id': 'simic2022', 'abstract': 'We propose and demonstrate a scheme for optical nanoparticle characterization, optofluidic force induction (OF2i), which achieves real-time optical counting with single-particle sensitivity, high throughput, and for particle sizes ranging from tens of nanometers to several micrometers. The particles to be analyzed flow through a microfluidic channel alongside a…

Extraordinary performance of semiconducting metal oxide gas sensors using dielectric excitation

{'id': 'potyrailo2020', 'abstract': 'Semiconducting metal oxides are widely used for gas sensors. The resulting chemiresistor devices, however, suffer from non-linear responses, signal fluctuations and gas cross-sensitivities, which limits their use in demanding applications of air-quality monitoring. Here, we show that conventional semiconducting metal oxide materials can provide high-performance…

Research: What Inclusive Companies Have in Common

{'id': 'cheng2021', 'abstract': 'A survey of more than 19,000 HBR readers found that one particular culture style differentiated the diverse and inclusive organizations from those that were not: a learning-oriented culture that emphasizes flexibility, open-mindedness, and exploration, and can equip organizations with the ability to adapt and innovate. To foster a learning-centric culture, leaders…

Continuous free-flow electrophoresis

{'id': 'krivankova1998', 'abstract': 'This review evaluates the literature on continuous free flow electrophoresis, published during the last four years. Its aim is to serve not only experts in the field but also newcomers, and, therefore, it also briefly describes the principles of the method and the techniques used, referring to fundamental papers published earlier. The actual commercial…

Competing oxygen evolution reaction mechanisms revealed by high-speed compressive Raman imaging

{'id': 'pandya2022', 'abstract': 'Transition metal oxides are state-of-the-art materials for catalysing the oxygen evolution reaction (OER), whose slow kinetics currently limit the efficiency of water electrolysis. However, microscale physicochemical heterogeneity between particles, dynamic reactions both in the bulk and at the surface, and an interplay between particle reactivity and electrolyte…

Design and Evaluation of a RESTful API for Controlling and Monitoring Heterogeneous Devices

{'id': 'lelli2011', 'abstract': 'In this paper we apply the REST principles to the problem of defining an extensible and lightweight interface for controlling and monitoring the operations of instruments and devices shared on the Grid. We integrated a REST Service in the Tiny Instrument Element (IE) that has been used for an empirical evaluation of the approach demonstrating that this…