Fusobacterium nucleatum is one of the key bacteria in the oral microbiota, which plays a key role in the structural integrity of dental plaque , an anaerobic bacterium. Emerging clinical evidence has increasingly linked this opportunistic pathogen to severe systemic pathologies, notably colorectal cancer and adverse pregnancy outcomes. This review synthesizes current genomic and molecular insights…
Background: Amino-sulfonic derivatives are recognized for their diverse biological roles, particularly in modulating physiological environments and cellular protection. Understanding their interaction with enzyme systems like carbonic anhydrase (CA) is crucial for developing therapeutic strategies against oxidative stress and metabolic imbalances. Objective: This study aims to systematically…
The inheritance pattern of mitochondrial DNA (mtDNA) from mother to offspring is well known, but the dynamics of heteroplasmy, the coexistence of more than one type of mtDNA molecule per cell, as well as the influence of the Genetic Bottleneck on the Variant Allele Frequency (VAF), are still under active research investigation. This study was conducted with the objective of detecting and analyzing…
Background: Insulin resistance (IR) is a significant metabolic abnormality that occurs prior to the onset of T2DM and is related to oxidative stress and micronutrient imbalance. Selenium (Se) and chromium (Cr) are trace elements that have important functions in the body, including as antioxidants and in regulating insulin action; however, the relationships between these trace elements and IR…
Psoriasis is a chronic inflammatory disease of immune-related origin. It is no longer classified solely as a localized skin disorder but is now recognized as a systemic disease associated with numerous complications and co-morbidities. Recent studies have demonstrated a strong link between psoriasis and several liver diseases, particularly non-alcoholic fatty liver disease (NAFLD), non-alcoholic…
Background: The research examined four desert plants, which included Artemisia monosperma , wild thyme , Achillea falcata , and Ephedra , which were collected from the Al-Salman desert area in Al-Muthanna Province, Iraq. The study assessed the methanolic and aqueous extracts to determine their extraction capacity while studying their chemical characteristics and their effects on kidney failure and…
Migraine is a common neurological illness marked by recurring headache episodes, followed by other neurological and gastrointestinal symptoms. While the precise pathophysiology of migraine is not fully elucidated, increasing evidence indicates that disruptions in histamine metabolism may significantly contribute to the onset of migraines. Diamine oxidase (DAO) is a crucial enzyme that facilitates…
Toxoplasma gondii is one of the world's most common parasitic infections, with well-known effects on the immune system but poorly understood effects on the endocrine system and inflammation. Emerging literature indicates that the parasite alters the hormonal balance of the host, which may play a role in the development of disease, inflammation and poor health outcomes. But the diagnostic and…
Laboratory animals, especially rodents, are essential models for biomedical research, and especially for studies of disease mechanisms. The current study was carried out at Al-Kut animal facility of College of Science, University of Wasit, Al-Kut, Iraq under controlled experimental conditions in a systematic evaluation of the physiological, biochemical and histopathological responses of laboratory…
Short tandem repeats (STRs) are highly polymorphic forensic DNA markers widely used in population genetics, paternity testing, forensic genetics, and human identification. In this research we aimed to provide a comprehensive evaluation of STR alleles as forensic markers and study genetic diversity across five major regions in Iraqis. Collection of buccal swab samples from 1345 random unrelated…
