THE MS-BLOG FOR PEOPLE AFFECTED BY MULTIPLE SCLEROSIS. INTERPRETING GOOD, BAD AND OTHER NEWS
Neuros are a spineless bunch as they surcome to pressure to do controlled trials with comparator drugs that are known to be inferior to the potential test drug. Historically pharma would test their new drug compared to a placebo, expected to do nothing. Whilst it is clear that being in a trial can have benefits [ ]
Manzano CL, Sadek A, Cooper C, Tomlinson E, Wang H, Rice C, Tallantyre E, Rao-Middleton A, Whiting P, Thom H. Natalizumab and Tyruko (natalizumab biosimilar) for treating highly active relapsing-remitting multiple sclerosis after at least one disease-modifying therapy: a systematic review and economic model. Health Technol Assess. 2026;30:1-290. Background: Multiple sclerosis is an immune-mediated…
There are lots of different B cell depleting antibodies used in cancer and autoimmunity. There are three approved for MS (in blue below. Ublituximab, ocrelizumab and ofatumumab), but rituximab is used a lot in some countries. The target binding bit of the antibodies give the specificity but the fragment crystallizable mediate the effector function of [ ]
ProfK has ben magnifying the cladribine natural history and they have got back to where we left off in 2010, when they threw cladribine out with the bath water. They say that cladribine has durable efficacy observed at 4 years following treatment initiation. Most participants maintained high NEDA-3 rates, low ARR and stable EDSS scores. With [ ]
Glial fibrillary Acid Protein is a protein found in astrocytes and it can be released and measured in the blood, just like neurofilament can be a marker of nerves. Having spent year researching neurofilament we now turn our attention elsewhere. There are claims that these markers allow you to look into the future like Mystic [ ]
Yes I am making a little bit of a joke here but every week we hear this or that causes MS and so we get vitamin D causes MS, smoking causes MS, obesity causes MS, Hamburgers cause MS, salt blah blah blah and the problem is always working out cause and effect. So I make [ ]
Everyone who has MS has been infected with Epstein Barr Virus as ProfG and others keep on telling us, but you only need a few examples to say that this is BS, and if is indeed BS and you have to look elsewhere. Just one case and it is not the essential cause, but one [ ]
The lastest immunology offerings have arrived and it is work in mice and I thought that I would have a look. I need to know more on innate lymphoid cells. Innate lymphoid cells (ILCs) are a recently described group of innate immune cells that are non-T cells and non-B cells that mirror the characteristics of [ ]
Maxwell CR, Turner TJ, Wallstroem E, Patel S, Pappas SC, Lewis JH, Andrade RJ, Syed S. Tolebrutinib liver safety: A detailed overview. Mult Scler Relat Disord. 2026;113:107404. Tolebrutinib is an oral brain-penetrant Bruton s tyrosine kinase inhibitor thought to modulate persistent maladaptive immune activation within the CNS. It was evaluated in four Phase 3 trials and [ ]
Maybe it is just me and I am abit of an old fart but I can t be bothered to do the endless stream of requests for a survey of How we did? I say the service is rubbish. Do they bother to react, especially as the surveys are often writing in a way to say [ ]