Max's Musings #2: Sequoia's Rating System, the Replicability Crisis in Research, Building Great Culture, and How to Kick Habitual Phone Use for Good.

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Welcome!

Each week, I share 3 learnings, 2 top conversations, and 1 challenge related to company building, health, productivity, and life.

At the bottom I highlight my ‘top finds’ for the week.

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1. Culture follows the power law

Great company culture is 10x more valuable than just good company culture.

So, it’s really important to invest in creating great company culture versus just good culture.

This is hard because going from good to great requires a lot of effort.

But, recognizing the power law of output in return for effort makes the effort easier to justify.

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2. Platform biotech might not be as promising as it sounds

Platform biotech is when a company uses a single technology or method to develop a range of products for different diseases.

For example, a platform biotech company might target ‘cancer’ generally whereas a vertical biotech might target ‘stage 2 lung cancer’.

Many of the largest biotech companies are platforms, but several savvy investors I know are skeptical of investing in early-stage platform biotech companies, particularly when AI is used.

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3: Only 40-60% of research papers can be replicated

This calls into question the extent to which we can trust papers.

The problem is that researchers are incentivized to publish something novel and get citations, which results in gaming the system.

This is why I find the best doctors don’t mindlessly follow papers.

The best doctors say “Let’s do x because I’ve seen it work in thousands of patients”.

Anecdote and observation are powerful.

After all, they’re the first step in the scientific method.

Just because there isn't a double-blind, randomized, placebo-controlled trial doesn't mean something's not true.

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1. Venture investing supports macro hedge fund investing

I spoke to a 21-year-old friend starting a VC fund alongside a systematic macro hedge fund.

He’s already raised from Marc Andreessen, Chris Dixon, and Josh Wolfe.

His key belief is that investing in deep tech startups helps you predict macroeconomic outcomes based on technology-related factors.

He believes VCs see the future before anyone else and that allows them to strategically buy/sell in public markets.

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Other partners can update it and change it, and they argue over ratings.

This shows the importance of doing good things consistently.

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My phone use has started going up in a habitual, compulsive, addictive way.

I'm solving this by keeping my phone in my bedroom for most of the day.

I’m planning to only use it when I intentionally choose to versus when I’m habitually compelled to.

I’m going to extend this to my computer by using distraction-blocking apps.

This helps me focus on the highest priority thing rather than the urgent, dopaminergic thing.

• I’ve been loving this silver toothpaste and this coconut oil mouthwash for oral health, which I shared as part of my oral health protocol here.

• The One Thing Naval Reinforces to Tim Ferriss

• Your Sodium to Potassium Ratio Should be 4:1