After compiling these resources for my personal reference, I realized that others may benefit from them as well. As a person of collaborative spirit, I decided to post them here! Although these are focused on early-stage biotech entrepreneurship, many of the resources should also have broader applicability. I should note that some of the items [ ]
PDF version: Notable Recent Events in Gene Therapy Translation January 2023 to January 2026 Clinical gene therapy has seen a lot of big wins and a lot of big setbacks over the past few years. To help myself keep track of recent important events in the field, I decided to write up this catalogue of [ ]
PDF version: The Path to Scalable Psychiatric Gene Therapy and a Future of Cures for Widespread Mental Illnesses By Logan Thrasher Collins The Promise of Psychiatric Gene Therapy Current psychiatric interventions remain insufficient to address the highly prevalent mental illnesses which plague more than a billion people (1 in 7) across the world.1 Widespread [ ]
PDF version: Amygdala Structure, Function, and Clinically Relevant Pathways by Logan Thrasher Collins Anatomy The amygdala consists of nuclei which can be grouped into (i) the basolateral nuclear group (BLA), (ii) the superficial cortex-like laminated region (sCLR) which contains the cortical nuclei (Co), and (iii) the centromedial nuclear group.1 The BLA consists of the [ ]
PDF version: An Introduction to Ebolavirus Biology Logan Thrasher Collins I wrote this educational primer as a fun exploration of a topic not related to my current research. While such knowledge may be useful in the event of some future ebolavirus epidemic, it is mostly just an exercise in curiosity and intellectual enrichment. I [ ]
Prelude This essay is intended as an intuitive examination of a reward system neural circuit which may serve as a useful target for new therapies aimed at fighting treatment-resistant depression (TRD). My purpose here is not to introduce an entirely novel concept, but rather to compile in one place a set of important explanations on [ ]
PDF version: Notes on Fundraising Mechanics for Startups by Logan Thrasher Collins Valuation A company’s valuation is initially an estimate of how much the company is worth as set by methods such as the following. Pre-money valuation is the company’s agreed-upon value before new capital is invested. It sets the price at which new shares [ ]
PDB 4V60: structure of a protein vault (MVP only) Structure and organization: Wild-type vaults consist of multiple copies of major vault protein (MVP), VPARP, and TEP1 proteins as well as small untranslated RNAs called vRNAs (Pupols, 2011). Vaults are ~13 MDa in mass if VPARP, TEP1, and vRNAs are included along with the 78 MVPs [ ]
PDF version: Notes on Ultrasound Physics and Instrumentation by Logan Thrasher Collins Fundamentals of ultrasound waves Sound waves such as those in ultrasound are longitudinal waves where particles oscillate backwards and forwards along the wave’s direction of propagation. This forms regions of higher (compression) and lower (rarefaction) density. Sound waves occur through the exchange [ ]
I presented these slides (PDF and images below) during the Workshop on Philosophy and Ethics of Brain Emulation (January 28th-29th, 2025) at the Mimir Center for Long Term Futures Research in Stockholm, Sweden. In my talk, I explored how various biological phenomena beyond standard neuronal electrophysiology may exert noticeable effects on the computations underlying subjective [ ]