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Lindsey Mack's Complexity Edge · Aug 21, 2026

What If Your ADHD Fatigue Isn’t ADHD?

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Lindsey Mackereth · Lindsey Mack's Complexity Edge

There is a particular kind of exhaustion that shows up as “I just can’t start.” As “my meds stopped working.” As “I used to be sharper than this.” As a client sitting across from you, describing a fog that has settled over a brain that used to move like weather, fast, associative, alive, and now moves like sediment.

I am not a physician. I am not a nutritionist. I am a psychotherapist who works with a lot of neurocomplex brains, ADHD, autistic, gifted, and every combination those labels create when they land in one nervous system. And I need to say something plainly, before I say anything else: I think we are missing a piece. Not a small one. Not a footnote. A piece that sits underneath a huge percentage of the fatigue, the fog, the “why isn’t this working anymore” that shows up in my office week after week, and I cannot stop thinking about the fact that almost nobody is naming it.

This is not a passing theory I picked up from one article. It came from a pattern I kept seeing across dozens of sessions, one that never fully made sense inside the explanations I already had, followed by a research rabbit hole I could not talk myself out of. The story we tell about ADHD and neurocomplex brains has a hole in it, and once I saw the hole, I could not unsee it. I have not been able to stop bringing it up since, with clients, with colleagues, with anyone who will sit still long enough to hear it out.

What follows is not medical guidance. It is a clinician’s conviction, backed by reading I have done, that something significant is being overlooked, and that you deserve to know it exists so you can bring it to the people who actually manage your bloodwork. I am not asking you to trust my authority on this. I am asking you to notice how strongly I feel about it.

We have gotten very good, in the ADHD and neurocomplex world, at talking about dopamine. Reward pathways, executive function, the prefrontal cortex as an under-fueled engine. It’s a good story. It’s also, on its own, an incomplete one, and I think we have all gotten comfortable enough with it that we stopped asking what else might be true.

What I don’t hear talked about enough, what I have started asking about in my own life and pushing on out loud with the people I work with, because I genuinely believe it is being missed, is:

Read the original on lindseymackereth.substack.com

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