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Lifespan Research Institute

Building a Future Free of Age-Related Disease

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In ALS, Microglia Eat Living Neurons, Mistaking Them for Dead

A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due to altered signaling [1]. The living dead Amyotrophic lateral sclerosis (ALS), […]

How Old Fat Cells Trigger Inflammation and Raise Risks

Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in mice and people. Too […]

GenBio Launches a “Virtual Cell” AI Model

This AI startup, which lists Nobel laureate David Baker among its co-founders, has announced a “world model” of a cell that can simulate both its natural […]

How Senescence Spreads Between Brain Cells

Researchers have gone into deep detail regarding how each of five senescent brain cell types expresses and receives factors that encourage other cells to become senescent. […]

A Million-Person Study Finds a Protective Metabolic Gene

A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and mice suggest a therapeutic route [1]. Longevity […]

A Drug Combination Fights Both Senescence and Cancer

In Aging, the Conboys and their team have described how a combination treatment kills both senescent and cancer cells and lengthens the lives of old mice. Of senescence and cancer Just […]

Forever Healthy Launches the Evipedia Browser Extension

Staying informed about health and longevity interventions can be tedious and time-consuming. Often it involves manually decoding a supplement label with numerous compounds, reading a blog post about some therapy, or an X-post that name-drops a peptide […]

The Thymus Hormone Thymulin Reduces Inflammaging in Mice

A recent study identified the thymus hormone thymulin as a molecule with the potential to reduce inflammation in an age-dependent manner. Treating cancer-bearing mice with this molecule made other cancer treatments more effective [1]. The aging immune system Aging […]

Why Affecting Aging in Complex Organisms Is So Hard

A new study proposes a theoretical framework that explains why the more complex an animal is, the harder it is to move the needle on its rate of aging [1]. A problem of great […]

A New Target Against High Blood Pressure

Researchers have discovered why the protein AGGF1 has significant effects on blood pressure and published their findings in Aging Cell. Blood pressure is a condition of its own The authors begin their paper by discussing […]

Wei-Wu He: People Should Become the CEOs of Their Own Health

Human Longevity Inc., a company founded in 2013 by a trio of visionaries – Craig Venter, Peter Diamandis, and Robert Hariri – […]