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Lev Lafayette · Aug 4, 2026

Maximum-Likelihood (ML) Phylogenetics in High Performance Computing

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Given a DNA or protein sequence, Maximum-Likelihood (ML) Phylogenetics searches for an evolutionary tree that would most probably have produced the observed sequences. This probability is based on a statistical model of how sequences evolve. For example, consider the DNA sequences for the following primates with standard DNA nucleotide abbreviations: adenine (A), cytosine (C), guanine (G), and…

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