The Singularity in Our Past Light-Cone The Specialist Is Now You. What AI enabled yesterday was a benchmark number. What AI enabled today is the individual, working alone, owning the whole pipeline from raw sequence to mechanistic call. by Justin Johnson, Apr 21, 2026 I reproduced Goodfire’s mechanistic variant-effect pipeline on cancer genes over a weekend. [ ]
A new therapeutic approach developed by McMaster researchers could help prevent brain cancer. Targets inosine monophosphate dehydrogenase 2 (IMPDH2), one of two enzymes researchers say is “vital” to metastases. Decline of Ph.D. Admissions Could Imperil a ‘Generation of New Talent . Some of the nation’s top research universities are shrinking doctoral programs because of uncertain federal [ ]
Mount Ida hike in RMNP. What is Tenebrescence? (All about Hackmanite Hint: it s not fluorescence) How To Talk to Anyone About OMB-2026-0034 AAAS Statement on OMB Rule Politicizing Federal Grantmaking Bullseye Glass Portland, Oregon: learn fused glass online. for free. Covid vaccine linked to broad protections against heart conditions, study finds. A new study [ ]
“They Would Never Use the Death Star on Us”: Alderaan Residents Reflect on Their Support for the Empire as a Large Imperial Installation Enters the System by Jack Loftus How the Bird Eye Was Pushed to an Evolutionary Extreme. The bird retina is one of the most energetically expensive tissues in the animal kingdom, yet it [ ]
Bluebird by Ciel Pierlot. The story follows Rig as she embarks on a journey across the galaxy to save her estranged sister from her former faction – who are trying to blackmail her into returning what she stole from them. The new moonshot by Jacinta Bowler, Joshua Byrd and Teresa Tan. The National Park Service [ ]
Unpublished Games Network (Unpub). We support the game design and development community by organizing events intended to help designers receive public playtests and feedback, and connect with other tabletop gaming industry folks. These events are open to anyone who wishes to bring their game to the table. Google Has a Secret Reference Desk. Here s How [ ]
Well, that was easier than expected. I followed the directions here: https://linuxvox.com/blog/install-ssl-certificate-ubuntu/. Added a Let s Encrypt certificate using certbot. Expires every 90 days. Auto-renew:
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Chicago did it, in 2025 we had the fewest murders recorded since 1965 416 in 2025, 395 in 1965! J6ers: Where Are They Now? Catching up with notorious insurrection offenders a year after Trump’s pardon spree. JD Vance Roasted After Comparing Trump Economy to ‘Titanic’ Nature article on cuts to Science funding under the Trump administration. [ ]
Reported in the Guardian, AI being used to help cut A E waiting times in England this winter by Hannah Devlin. The A E forecasting tool predicts when demand will be highest, allowing trusts to better plan staffing and bed space. The prediction algorithm is trained on historical data including weather trends, school holidays, and rates [ ]