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De Novo

All things synthetic.

denovo.substack.comSource feed ↗10 episodes

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Gene drives meet germline biology

Promoters gonna promote

On the (im)possibility of self-fertile human hermaphrodites

I recently read a rather unusual article, discussing the possibility that certain humans may be able to conceive and bear children completely on their own.

Merrick Biotech and Ovelle Bio Announce Definitive Merger Agreement

In vitro oogenesis. Now with 200% more Michael Bay!

What happens when you clone mice for 20 years straight?

This story begins in 1997, the same year I was born.

Three interesting studies of genetic variation

Meiosis errors, Epstein-Barr virus, and lifespan

What makes a good egg?

Desiderata for in vitro oogenesis

Androgenetic haploid selection

How abundant eggs can increase the power of genetic selection (even if the eggs are not very good)

Bio links, Fall 2025

Some interesting stuff I've read recently

Gratitude for life

A few days ago, I got a call at 2:39 a.m.

A profile in courage

On DNA computation and escaping a local maximum