What Reading Edward Feser’s Introduction to Scholastic Metaphysics Taught Me About B2B SaaS
If you’re wondering “is this a joke,” the answer is both yes and no.
Corin Wagen
My personal blog: chemistry, theology, metascience, and whatever else I'm thinking about.
Live Last read · last published · next check
Latest posts
Towards an Anagogical Reading of “Venice Bitch”
TW: profanity, sarcasm, misuse of theological concepts.
Small Molecules Have More Information Per Atom Than Biologics
Something I’ve been thinking about recently is the information content of different biomolecules.
Tool Use and "AI Scientists"
As AI systems get more powerful and better at scientific tasks, what will the new research ecosystem look like?
Multiparameter Compound Optimization with LLMs
Yesterday, an interesting paper was released by Prescient Design (Genentech), “Evaluating the Progression of Large Language Model Capabilities for Small-Molecule Drug Design.” The authors formulate a variety of problems in small-molecule drug design as reinforcement-learning (RL) problems and use RL-based post-training to improve the performance of a 30B-parameter Qwen model (specifically,…
Book Review: The Reformation As Renewal
TW: stridently anti–Roman Catholic rhetoric, medieval realist metaphysics
Horizontalization in Biotech
Long ago, there were no software companies.
Books from 2025
(Previously: 2022, 2023, 2024.)
Seven Thoughts on "AI Scientists"
Last week I had the privilege of attending the 2025 Progress Conference, which brought together a diverse cadre of people working on progress, metascience, artificial intelligence, and related fields.
Vibe-Coding a Coloring-Page Generator
I don’t write about my non-working life much on the Internet; my online presence has been pretty closely tied to Rowan and I try to adhere to some level of what Mary Harrington calls “digital modesty” regarding my family.