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The concept of p K a is introduced so early in the organic chemistry curriculum that it’s easy to overlook what a remarkable idea it is. Briefly, for the non-chemists reading this: p K a is defined as the negative base-10 logarithm of the acidity constant of a given acid H–A: p K a := -log 10 ([HA]/[A-][H+]) Unlike pH, which describes the acidity of a bulk solution, p K a describes the intrinsic…
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