The A to Z of Life Sciences, AZoLifeSciences, is a free-to-access information portal with the latest news, articles, videos, equipment and interviews from the life sciences community.
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Inside every cell, thousands of proteins must reach the right place at the right time. Helping coordinate this complex logistics network are centriolar satellites-tiny, membrane-less organelles that play important roles in protein trafficking, cell division, and the formation of cilia.
Understanding how molecular changes shape brain function and disease requires more than measuring genes in bulk tissue.
A two-headed molecule designed by Stanford Medicine researchers hijacks one of the most common protein drivers of B-cell lymphoma, flipping it from its role as a promoter of cell growth into an arbiter of cell death.
Researchers at the University of Cologne, University Hospital Cologne, and the Max Planck Institute for Metabolism Research have developed a method that, for the first time, enables damage to individual cells to be precisely quantified.
Precise activation of tens of thousands of genes is critical for healthy development and growth. Specialized segments of our DNA are responsible for carefully orchestrating genetic sequences that result in the production of enzymes, hormones, proteins and other crucial components underlying cell structure and function.
Stopping tumor growth is only half the battle. Rather than kill tumor cells, many cancer therapies can only push them into cellular senescence, a state in which cells stop dividing but do not die. These "undead" cells will continue to release signals that reshape the tumor environment.
Cancer patients often face more than the disease itself. Their treatment is frequently complicated by infections and other health conditions, meaning they may need to take several different medications at once.
A human, an octopus, and a coral could hardly look more different - yet deep inside their cells, their chromosomes still carry recognizable pieces of a genome inherited from an animal ancestor that lived more than 600 million years ago.
Biology doesn’t happen at one scale. Molecular interactions unfold in milliseconds and nanometers, while disease-associated change such as in Alzheimer’s spreads across millimeters of brain tissue.
In a new study, scientists from Johns Hopkins Medicine report that an experimental mRNA-based platform has the potential to help deliver next-generation mRNA therapeutics, including vaccines fighting against infectious disease, cancer and autoimmune conditions, faster and more efficiently than the industry standard.
Selenosugars are the major urinary metabolites responsible for the physiological excretion of selenium. Understanding selenium metabolism relies on accurately detecting and identifying selenosugars.
If you want to describe a particular color, you could look to the Pantone color wheel to find its exact hue, saturation and brightness, and how it compares to other colors. But nothing like that has existed for complex odors.
The human brain is often described as one of the most complex structures in biology, and much of its power comes from how it's organized.
All living things have a fleet of tiny copy machines that turn instructions from DNA into RNA, the molecules responsible for helping build proteins that keep organisms alive.
Drug-target interaction prediction can help researchers explain mechanisms of action, identify candidate targets, reposition existing medicines and prioritize compounds before costly laboratory work.
Whether you are characterizing cell state transitions, assessing organelle integrity, or building a multiplex immunofluorescence (IF) assay, you need reliable structural markers for your imaging.
In people with type 1 diabetes, the immune system mistakenly destroys the pancreatic beta cells responsible for producing insulin. Patients therefore require lifelong insulin therapy to regulate their blood glucose levels.
Most people carry the fungus Cryptococcus neoformans in their lungs for life and never know it, held in check by the immune system.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that, according to the CDC, currently impacts around 35,000 Americans-with 5,000 more diagnosed each year.
When our immune system detects a pathogen or injury, it sets off biological alarm bells. This alert brings in a variety of immune and other cells to deal with the threat and heal any harm done.
Focusing on complementarity-determining regions in antibody models leads to better binding affinity predictions, potentially accelerating treatment discovery.
Scientists have redefined how the key blood‑clotting protein fibrinogen behaves when it contacts air, overturning two decades of scientific consensus on wound healing.
Drawing inspiration from the dynamic architecture of living systems, researchers from Institute of Science Tokyo and Kyoto University have harnessed two chemically fueled biomolecular nanomachines, DNA polymerase and kinesin, to synthesize and actively assemble complex, hierarchical DNA networks.
Researchers at Washington University School of Medicine in St. Louis have discovered lymph node-like structures in the skull bone marrow of mice for the first time and demonstrated that they act as rapid first responders against brain cancer before distant lymph nodes get the signal that abnormal cells are present.
Why does staying awake inevitably make us sleepy? Researchers at the University of Basel, Switzerland, have identified neuronal populations in the brain of mice that become activated during prolonged wakefulness and are crucial for sleep drive.
A landmark global study including University of North Carolina eating disorder expert Cynthia Bulik, Ph.D., FAED, has, for the first time, mapped and compared the genetic profiles of binge eating and anorexia nervosa.
Researchers from University of California San Diego and collaborators have identified a previously overlooked pattern of DNA mutations in colorectal cancer.
One of the most important milestones in the early life of an organism is when the embryo breaks symmetry and arranges itself to form the head (anterior) at one end and tail (posterior) at the other end.
Scientists at VIB and Ghent University have produced the first high-resolution, cell-by-cell map of how tomato roots respond to colonization by arbuscular mycorrhizal fungi.
Scientific progress comes not only from discovering something entirely new, but also from taking a fresh look at long-held assumptions.
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