# Gary Tom — RSS Amplifier Everything Gary Tom publishes, via the RSS Amplifier directory. Page: Feed: --- ## [The Hidden Cost of Quantum Simulation](https://aspuru.substack.com/p/the-hidden-cost-of-quantum-simulation) _2026-07-20 · The Matter Blotter_ Quantum simulations are essential because nature is quantum. ## [This AI Agent Doesn’t Come With Tools. It Forges and Reuses Them](https://aspuru.substack.com/p/this-ai-agent-doesnt-come-with-tools) _2026-06-30 · The Matter Blotter_ Meet El Agente Forjador - Agent that forges scientific tools ## [Inside a Self-Driving Lab for Materials Discovery](https://aspuru.substack.com/p/inside-a-self-driving-lab-for-materials) _2026-06-01 · The Matter Blotter_ A materials scientist’s firsthand experience with the potential of autonomous experimentation ## [What Quantum Chemistry Teaches Us About Building Research Agents](https://aspuru.substack.com/p/what-quantum-chemistry-teaches-us) _2026-05-25 · The Matter Blotter_ With El Agente Quntur, we demonstrate that quantum-chemistry agents should be built around reusable research capabilities, rather than a collection of task-specific procedures or skills. ## [Bulky ligands promote palladium-catalyzed protodeboronation](https://aspuru.substack.com/p/bulky-ligands-promote-palladium-catalyzed) _2026-01-19 · The Matter Blotter_ A story of how a failed organic laser synthesis led us to uncover the mystery of palladium‑catalyzed protodeboronation. ## [Agentic AI Is Coming to Science—But What Should It Actually Do?](https://aspuru.substack.com/p/agentic-ai-is-coming-to-sciencebut) _2026-01-11 · The Matter Blotter_ An invitation to scientists to help shape the next generation of El Agente [Listen](https://api.substack.com/feed/podcast/184226268/a41ce75e587cf4f6d5cd517331306aab.mp3) ## [On rigorous benchmarking for agentic science](https://aspuru.substack.com/p/on-rigorous-benchmarking-for-agentic) _2025-12-18 · The Matter Blotter_ Setting the waterline so all boats can rise. [Listen](https://api.substack.com/feed/podcast/181943766/27742b6c4a31f18ebebdc32106e8a810.mp3) ## [Ranking Models for Bayesian Optimization](https://aspuru.substack.com/p/ranking-models-for-bayesian-optimization) _2025-12-15 · The Matter Blotter_ In self-driven molecular discovery, when you care about which molecules are best rather than how much better they are, train your Bayesian optimization surrogate to rank candidates instead of predicting exact values. ## [AI Agents Are Now Running Quantum Experiments. Here’s How](https://aspuru.substack.com/p/ai-agents-are-now-running-quantum) _2025-12-05 · The Matter Blotter_ Current AI agents have demonstrated remarkable capabilities in many tasks. But how about conducting research experiments? ## [The springs and sticks model](https://aspuru.substack.com/p/the-springs-and-sticks-model) _2025-11-28 · The Matter Blotter_ A simple system that can learn any function with interesting physics! ## [Countdown to Getting Paid (Sponsored)](https://crawlproof.com/a/voY85TDO5zsB) _2025-11-28 · **Sponsored**_ Create a shareable wallet timer — deposits buy back time and pay debt down ## [HIP: Hessian Interatomic Potentials](https://aspuru.substack.com/p/hip-hessian-interatomic-potentials) _2025-11-04 · The Matter Blotter_ Reaction rates, SE(3)-equivariance, and how Hessians improve energies and forces. ## [Podcast 2: Keep it Simple with Strings!](https://aspuru.substack.com/p/podcast-2-keep-it-simple-with-strings) _2021-12-07 · The Matter Blotter_ How string representations with simple language models can represent complex molecular distributions. [Listen](https://api.substack.com/feed/podcast/45142766/ce11794feaf45226933dc88ad26d265d.mp3) ## [Podcast 1. Reacting to inSilico AI's AI-discovered drug trials.](https://aspuru.substack.com/p/podcast-1-reacting-to-insilico-ais) _2021-12-05 · The Matter Blotter_ AI-discovered drugs and materials start to deliver in the commercial world. [Listen](https://api.substack.com/feed/podcast/45027860/da1289a049de501e2cc52f6c438a6a7e.mp3) ## [Revving up this substack](https://aspuru.substack.com/p/revving-up-this-substack) _2021-11-28 · The Matter Blotter_ And briefly describing the Acceleration Consortium. ## [Molecular graph representations and SELFIES: A 100% robust molecular string representation](https://aspuru.substack.com/p/molecular-graph-representations-and) _2021-01-11 · The Matter Blotter_ SELFIES is a new molecular representation with an exciting set of properties and applications. ## [Standing on the shoulder of giants.](https://aspuru.substack.com/p/standing-in-the-shoulder-of-giants) _2020-10-06 · The Matter Blotter_ Near-term quantum algorithms can benefit from the power of classical algorithms. ## [Bits are cheap and qubits expensive.](https://aspuru.substack.com/p/bits-are-cheap-and-qubits-expensive) _2020-09-07 · The Matter Blotter_ Making the most of qubits in VQE by basis-set-free methods ## [Quantum Research Seminars Toronto](https://aspuru.substack.com/p/quantum-research-seminars-toronto) _2020-08-03 · The Matter Blotter_ Creating an online community for quantum algorithms research. ## [Materials Acceleration Platforms](https://aspuru.substack.com/p/materials-acceleration-platforms) _2020-07-31 · The Matter Blotter_ Accelerating the discovery of materials. ## [CLI-first decentralized compute (Sponsored)](https://crawlproof.com/a/ojQAPzhdwXzR) _2020-07-31 · **Sponsored**_ Run and pay spare GPUs from the CLI — transcode, coinpay (DID+escrow), infernet (AI). ## [Designing quantum hardware with quantum computers](https://aspuru.substack.com/p/designing-quantum-hardware-with-quantum) _2020-06-25 · The Matter Blotter_ Quantum computer-aided design