The goal of BayesianPlatformDesignTimeTrend is to simulates the multi-arm multi-stage or platform trial with Bayesian approach using the ‘rstan’ package, which provides the R interface for to the stan. The package uses Thall’s and Trippa’s randomisation approach for Bayesian adaptive randomisation. In addition, the time trend problem of platform trial can be studied in this package. There are a some demos for the simulation process of cutoff screening, hyperprameter tuning and design evaluation in this package.

Installation

You can install the ‘BayesianPlatformDesignTimeTrend’ package 1.2.0 like so:

# install.packages("BayesianPlatformDesignTimeTrend")
# devtools::install_github("ZXW834/BayesianPlatformDesignTimeTrend", build_vignettes = TRUE)

Bayesian simulation process overview

In the design,