Monolog 32 - When Proteins started writing DNA
In this monolog, Vijay talks about a paradigm shifting publication from 2026 showcasing protein-templated DNA synthesis.
Antibuddies
Everything about immunology
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Monolog 31 - Sound the interferon alarm
In this monolog, Casey talks about a 2025 report highlighting the role of SARS-CoV-2 mRNA vaccine in sensitizing cancer patients to immune checkpoint inhibitor therapy.
Monolog 30 - The glia doesn't forget
In this monolog, Vijay talks about a 2026 article that showed there is epigenetic memory in adult glial cells that allows them to regenerate but also paves the way for their malignant transformation.
Monolog 29 - Agnatha All Along: The immune system of the jawless fish
In this monolog, Akshat (the returned prodigal) discusses the comparative immunology of jawless fish and jawed vertebrates and the fascinating ways in which the seemingly primeval immune system of the hagfish shows sophistication equal to the immunoglobulin superfamily-based adaptive immune response of humans and other jawed vertebrates.
Monolog 28 - Archives of a cell
In this monolog, Vijay talks about TimeVault, a novel technology that allows capturing and storing mRNA in mammalian cells. Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast). YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com. Website: Antibuddies –…
Monolog 27 - Discovery of NK cells (Part-3)
In this multipart monolog, Jatin talks about some milestone discoveries related to natural killer cells.
Monolog 26 - Beta cell death paradox in T1D
Vijay talks about a 2025 publication delineating the role of efferocytosis by pancreatic macrophages in modulating type I diabetes.
Monolog 25 - Skintabodies
In this monolog, Casey talks about a recently discovered role of Skin in autonomously producing antibodies against microbes.
Monolog 24 - Discovery of NK cells (Part-2)
In this multipart monolog series, Jatin talks about some milestone discoveries related to natural killer cells. Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast). YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com. Website: Antibuddies – Science…
Monolog 23 - ILC you in pancreas 2
In this monolog, Vijay talks about a novel discovery highlighting the role of Innate lymphoid cells in regulation of blood glucose in fasting condition. This is the second part in the 2-part series.
Monolog 22 - ILC you in pancreas
In this multipart monolog, Vijay talks about a novel discovery highlighting the role of Innate lymphoid cells in regulation of blood glucose in fasting condition. This is the first part to the 2-part series.
Monolog 21 - Discovery of NK cells (Part-1)
In this multipart monolog, Jatin talks about some milestone discoveries related to natural killer cells. Check out our memes on Facebook (@antibuddies), Twitter (@antibuddiesP), and Instagram (@AntibuddiesPodcast). YouTube channel: https://www.youtube.com/channel/UCxyrHotyyY3sSwcp1zigeCw Send us your queries/questions/suggestions at antibuddies1@gmail.com. Website: Antibuddies – Science…
Monolog 20 - The Fountain of IL-11 Youth
In this monolog, Casey discusses a 2024 article about the increase in health and lifespan in mammals after IL-11 inhibition.
Monolog 19 - Term vs Pre-term immune development
In this monolog, Vijay discusses the difference in immune system development in term and pre-term babies. Sources: https://pubmed.ncbi.nlm.nih.gov/30142345/
Monolog 18 - Interleakin'
In this monolog, Akshat ponders about the spatiotemporal underpinnings of cytokine concentrations in tissue niches...and how it all appears to function like a gossip network.
Monolog 17 - CAR-T and TCR-T Cells Face Off!
In this episode, Akshat outlines the salient features of CAR or TCR-engineered T cells, and deigns to ponder: is one modality just objectively better than the other?
Monolog 16 - 217 COVID boosters and counting
In this Monolog, Casey discusses the unique case of a hyper-vaccinated individual in Germany with more than 200 COVID-19 vaccines and how his immunological profile looks like.
Monolog 15 - The Liver is Bile-lingual
In this Monolog, Akshat discusses how the liver "speaks" both immunity and metabolism via bile to control hepatic tumors. Liver X Receptors also make an appearance.
Ep29 - Barrier immunity & the gut
In the 29th episode of our Immunology 101 series, Ash and Tanu start the new year 2024 with a discussion on Barrier Immunity with a focus on the gut.
Monolog 14 - Sterile inflammation
In this monologue, Akshat talks about sterile inflammation, or leucocyte activation in the absence of inflammatory responses. These carefully regulated "internal affairs" of the immune system can be pathological or protective.
Monolog 13 - Sleep tight, don't let the cytokine storm bite
In this monolog, Casey talks about a 2023 article from the National Institute of Biological Sciences (Beijun, China) about the role of cytokines and immune cells in sleep deprivation-induced mortality. Source: Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals - PubMed (nih.gov)
Monolog 12 - Gut is the multiverse of neuroimmune activities
In this monolog, Vijay talks about a 2016 article from Rockefeller University about the complex crosstalk in the gut between the neurons and macrophages.
Ep28 - The Natural killers
In the 28th episode of our Immunology 101 series, Ash and Jatin talk continue discussion on cytotoxic T cells and transition into their functional cousins - the natural killer cells.
Ep27 - The kiss of death
In the 27th episode of our Immunology 101 series, Ash and Jatin talk about how cytotoxic T cells deliver the kiss of death to their targets.
Ep26 - Cytotoxic T cells
In the 26th episode of our Immunology 101 series, Ash and Jatin shift gears from humoral immunity to cellular immunity and discuss cytotoxic T cell activation.
Ep25 - Fc receptors & Antibody isotypes
In the 25th episode of our Immunology 101 series, Koshika and Jatin discuss Fc receptors and Antibody isotypes and relate them to specific effector functions.
Ep24 - Antibody effector functions
In the 24th episode of our Immunology 101 series, Ash and Jatin discuss the various effector functions of Antibodies
Ep23 - Somatic hypermutation and Class switching
In the 23rd episode of our Immunology 101 series, Ash, Koshika, and Jatin discuss the events taking place inside the germinal center - class switching and somatic hypermutation.
Ep22 - B cells in the germinal center
In the 22nd episode of our Immunology 101 series, Ash, Koshika, and Jatin talk about the events of the germinal centers.
Ep21 - Fate of a B cell
In the 21st episode of our Immunology 101 series, Ash and Jatin talk about the fate of the B cell after it encounters the antigen and how it travels through the various compartments of a secondary lymphoid organ.
Bep40 - Non-canonical T cell activation in TDLNs
In this Buddisode, we sit down with Dr. Nataliya Prokhnevska to discuss her work on the fate and role of non-cytotoxic CD8+ T cells found in the tumor-draining lymph nodes of cancer patients.
Monolog 11 - Neuro-Pancreas Chat
In this monolog, Vijay talks about a recent article describing the communication between the vagus nerve and the pancreas.
Ep20 - B cells are mean
In the 20th episode of Immunology 101 series, Ash, Koshika, and Jatin shift gears to talk about B cell activation and draw parallels with T cell activation process.
Ep19 - Memory T cells
In the 19th episode of the Immunology 101 series, Ash, Koshika, and Jatin talk continue their conversation about T cell subsets with a focus on memory T cells.
Ep18 - T helper classification and polarization
In the 18th episode of Immunology 101 series, Ash, Koshika, and Jatin talk about classification of T helper cells and their functions.
Bep39 - How SARS CoV2 aces cytotoxic T cells
In this Buddisode, we sit down with Drs. Cosima T Baldari & Rino Rappuoli to discuss their work on a unique immune evasion strategy deployed by SARS CoV2 to paralyze cytotoxic T cells.
Ep17 - T cell activation
In the 17th episode of Immunology 101 series, Natalie and Jatin talk about the T cell activation process and make some very lame jokes.
Monolog 10 - Evolution of Immunity
In this monolog, Natalie talks about the evolutionary history of the immune system.
Bep38 - Yin and Yang of Tfh
In this Buddisode, we sit down with Dr. Simon Bélanger from the La Jolla Institute of Immunology (currently at Vir Biotechnology) to discuss his work on a transcription factor that can define early T follicular helper cell fate.
Bep37 - You won't believe what your eosinophils are doing!
In this Buddisode, we sit down with Dr. Emilie Cosway from the Institute of Immunology and Immunotherapy at the University of Birmingham (UK) to discuss her recent paper about the mechanisms behind thymic regeneration.
Bep36 - IL17A and ICI-induced autoimmune thyroiditis
In this buddisode, we sit down with Dr. Melissa Lechner from the Division of Endocrinology, Diabetes, and Metabolism at the UCLA David Geffen School of Medicine to discuss her recent paper about the mechanisms behind immune checkpoint inhibitor-induced autoimmune thyroiditis.
Bep35 - Aging affects Central Tolerance
We sit down with Dr. Jessica Lancaster from the Department of Immunology, Mayo clinic to discuss her recent paper about the effect of Aging on Central Tolerance and Treg induction.
Ep16 - Pathways of the Complement System
In the 16th episode of Immunology 101 series, Natalie and Jatin talk about an undergrad's worst nightmare 2 months into the immunology course - The complement system.
Bep34 - A tale of labor, pre-term birth, and IL-22
We sit down with Dr. Nardhy Gomez-Lopez from the Department of Obstetrics and Gynecology at Wayne State University to discuss her recent paper about the role of IL-22 in pregnancy and pre-term births.
Ep15 - Regulation of Innate Immunity
Natalie and Jatin talk about positive and negative regulation in immune response, how the cells of the innate immunity interact with the adaptive, and the ubiquity of the immune system across phyla.
Ep14 - Innate Immune Cells
In the 14th episode of Immunology 101 series, Natalie and Jatin talk about the cellular facet of the innate immune system.
Bep33 - Transgenerational trained immunity
Eugenio and Jatin sit down with Dr. Jorge-Dominguez Andres (Ph.D.) from Radboud University to discuss trained immunity and its transgenerational inheritance in mice.
Bep32 - 6 shades of NF-kB #2
We continue our discussion with Dr. Adewunmi Adelaja (M.D., Ph.D.), from the University of California Los Angeles, about NFkB signaling and how signals to different stimuli are relayed inside macrophages.
Bep31 - 6 shades of NF-kB #1
We sit down with Dr. Adewunmi Adelaja (M.D., Ph.D.) from the University of California Los Angeles to discuss NFkB signaling and how signals to different stimuli are relayed inside macrophages.
Monolog 9 - Why do we lose smell after COVID19?
In this monolog, Tanu breaks down a recent study that elucidates the mechanism behind the loss of sense of smell in COVID19 patients.