D-dimer and fibrinogen

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D-dimer Mathematics!

Fibrinogen = 3 domains = central E + 2D

Thrombin cleaves fibrino-peptides (A and B) in E = Fibrin monomers

With fibrin-peptides A and B gone the monomers can polympermize

Fibrin monomers polymerize = Fibrin polymers

FXIIIa crosslinks D in polymers = (D-D)E-(DD)E... = cross linked fibrin and clot stabilized!

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