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1. In an observational study of pediatric patients, melatonin use may be associated with a decreased percentage of rapid eye movement (REM) sleep compared to melatonin nonusers. Evidence Rating Level: 2 (Good) Melatonin has been used by up to 19% of pediatric patients in the past 30 days. It is available without a prescription, and […] The post Melatonin use is associated with lower proportions of…
1. Epidural analgesia in labour is not associated with significant risk of neonatal neurological morbidity, neonatal morbidity or mortality. Evidence Rating Level: 2 (Good) Epidural analgesia during labour is regarded as the most effective form of pain control, which is important given that poor pain control may lead to physiological stress in mothers with important […] The post Epidural analgesia…
NHS England is rolling out Microsoft Copilot to 505,000 clinicians after a 30,000-person trial saved nearly an hour of admin time per day Recently, NHS England announced it will deploy Microsoft 365 Copilot to 505,000 clinicians and support staff, following a nine-month pilot across 30,000 workers at 90 NHS organizations. The headline result from that […] The post 2MM: AI Roundup: NHS England…
1. Among children with inflammatory bowel disease, there were no significant differences in serious or outpatient infection risk between initiating infliximab (Remicade) and adalimumab (Humira). Evidence Rating Level: 2 (Good) Study Rundown: Pediatric Inflammatory Bowel Disease (IBD) includes Crohn disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U), and its prevalence is…
1. The association between parental body mass index (BMI) and offspring BMI from age 6 months to 8 years may primarily be due to genetic confounding. Evidence Rating Level: 2 (Good) Although parental body mass index (BMI) has been associated with offspring adiposity in childhood, the mechanisms behind this relationship remain unclear. This study thus […] The post The association between parental…
Food and Drug Administration reviews artificial intelligence tool for liver injury prediction The Food and Drug Administration (FDA) is reviewing an artificial intelligence based drug development tool designed to predict drug induced liver injury, one of the more stubborn safety problems in clinical development. The agency’s Center for Drug Evaluation and Research accepted a letter […] The post…
1. After accounting for plurality, children conceived through infertility treatments showed similar growth trajectories to those conceived naturally. Evidence Rating Level: 2 (Good) Compared to children conceived naturally, children conceived through medically assisted reproduction (MAR) may experience different birth outcomes and growth patterns. However, evidence on long-term growth trajectories…
1. Exposure to adverse pregnancy outcomes, particularly hypertensive disorders of pregnancy, was associated with worse cardiovascular health and early arterial injury among offspring in early adulthood. Evidence Rating Level: 2 (Good) Study Rundown: Adverse pregnancy outcomes (APOs) have been associated with long-term maternal cardiovascular health (CVH). However, research on the role of APOs in…
1. Five days of accelerated continuous theta burst stimulation (a-cTBS) targeting the left primary motor cortex improved social communication impairment in children with autism spectrum disorder. Evidence Rating Level: 1 (Excellent) Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation technique that has shown efficacy in treating various neuropsychiatric…
1. Adopted individuals who experienced improved environmental conditions had better long-term psychosocial outcomes than their unadopted biological siblings, with some advantages also observed in the next generation. Evidence Rating Level: 2 (Good) Improving home environments during early life can benefit later cognitive, educational, and behavioural outcomes. However, the long-term protective…
