Concise. Curated. Evidence.™
Live Last read · last published · next check
1. Administration of perioperative intravenous vitamin C for percutaneous renal biopsy may not reduce the rate of bleeding complications. Evidence Rating Level: 1 (Excellent) PRB is an essential procedure for diagnosing many kidney diseases. As an invasive procedure, it carries inherent side effects of bleeding and pain. Although PRB is minimally invasive, severe hematomas can […] The post…
1. In this interim analysis from a randomized controlled trial, adults with biopsy-proven IgA nephropathy and persistent proteinuria who received telitacicept had improved proteinuria compared to placebo. 2. Telitacicept was associated with more overall adverse events but fewer serious adverse events and more stable kidney function. Evidence Rating Level: 1 (Excellent) Study Rundown: IgA…
1. A 4-week intradialytic pedalling exercise program was safe and well-tolerated but did not significantly improve dialysis adequacy measures. Evidence Rating Level: 1 (Excellent) This randomized controlled trial evaluated whether intradialytic pedaling exercise improves dialysis adequacy in adults with chronic kidney disease undergoing maintenance hemodialysis. Eighty-four patients from dialysis…
1. Renal point-of-care ultrasound (rPOCUS) findings of hydronephrosis in adult patients presenting to the emergency department (ED) with suspected renal colic were significantly associated with the presence of nephrolithiasis. Evidence Rating Level: 2 (Good) Computed tomography (CT) is the best imaging modality for identifying nephrolithiasis. However, it exposes patients to radiation, leads to…
1. Sparsentan (Filspari) becomes the first approved treatment specifically for focal segmental glomerulosclerosis. 2. Clinical trial data show meaningful reductions in proteinuria, a key marker of disease progression. The FDA granted full approval to sparsentan (Filspari) on April 13, 2026, for the reduction of proteinuria in adult and pediatric patients with focal segmental glomerulosclerosis.…
1. Renal point-of-care ultrasound (rPOCUS) findings of hydronephrosis in adult patients presenting to the emergency department (ED) with suspected renal colic were significantly associated with the presence of nephrolithiasis. Evidence Rating Level: 2 (Good) Computed tomography (CT) is the best imaging modality for identifying nephrolithiasis. However, it exposes patients to radiation, leads to…
1. In this phase 3 trial involving patients with type 1 diabetes and chronic kidney disease, finerenone was associated with significantly greater decreases in urinary albumin-to-creatinine ratio as compared to placebo. 2. Finerenone had an overall favorable safety profile but was associated with higher rates of hyperkalemia than placebo. Evidence Rating Level: 1 (Excellent) Study […] The post…
1. In this systematic review, low-strength evidence suggests that increased fluid intake, dietary modification (normal-to-high calcium, low protein, low sodium), and pharmacologic therapies (thiazides, alkali therapy, allopurinol, and acetohydroxamic acid) may reduce kidney stone recurrence in adults. 2. The overall strength of evidence is limited, as most included studies had moderate-to-high…
1. Adherence to the EAT-Lancet planetary health diet is associated with a lower risk of developing chronic kidney disease (CKD), which is partly mediated by specific metabolic and proteomic pathways. Evidence Rating Level: 1 (Excellent) Chronic kidney disease (CKD) is widespread, affecting 10% of adults globally, with diet playing a key role in reducing the […] The post A planetary health diet is…
1. In this retrospective cohort study, faster 24-hour sodium correction rates were associated with lower risk of 90-day death or delayed neurologic events in severe hyponatremia. 2. Higher-risk patients experienced larger absolute benefits, while relative effects were consistent across groups. Evidence Rating Level: 2 (Good) Study Rundown: Current clinical guidelines recommend slow correction of…
