1. Hematologic inflammatory indices in emergency department patients with COVID-19 showed an age-dependent prognostic performance for 30-day mortality, with systemic immune-inflammation index showing good discriminatory performance in patients <65 years and poorer performance in patients >65 years. Evidence Rating Level: 2 (Good) Hematologic markers derived from the complete blood count (CBC)…
1. In this cost analysis, the 2025 measles outbreak in New Mexico was estimated to impose a societal economic burden of $5.4 million, equivalent to approximately $53,500 per case. 2. Public health response activities accounted for the majority of costs, with more than $2 million devoted to vaccination-related efforts aimed at controlling the outbreak. Evidence […] The post New Mexico measles…
1. In the treatment of Clonorchis sinensis, albendazole (Zentel) demonstrates a high egg reduction rate but a significantly lower cure rate compared to praziquantel (Biltricide). Evidence Rating Level: 1 (Excellent) Study Rundown: Clonorchiasis is caused by infection with Clonorchis sinensis, a helminth parasite, and can lead to significant morbidities, including cholelithiasis, cholangitis,…
1. In a multicenter, single-blind, randomized clinical trial, participation in a cognitive rehabilitation program improved goal attainment and cognitive test scores in patients suffering from Long COVID-related cognitive dysfunction. Evidence Rating Level: 1 (Excellent) Long COVID is defined as a chronic condition that occurs following the infection of COVID-19, present for at least 3 months […]…
1. In this international randomized controlled trial of adults with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, cefazolin was noninferior to antistaphylococcal penicillins for 90-day mortality. 2. Cefazolin was also associated with fewer adverse events, particularly lower rates of acute kidney injury and treatment discontinuation due to toxicity. Evidence Rating Level: 1…
1. In this single-group, open-label trial, olorofim was associated with a complete or partial clinical response in over 75% of patients with disseminated coccidioidomycosis (DCM) and limited or no treatment options. 2. Clinical success rates were highest among patients without central nervous system (CNS) infection. Evidence Rating Level: 2 (Good) Study Rundown: Every year, thousands […] The post…
1. Among children with inflammatory bowel disease, there were no significant differences in serious or outpatient infection risk between initiating infliximab (Remicade) and adalimumab (Humira). Evidence Rating Level: 2 (Good) Study Rundown: Pediatric Inflammatory Bowel Disease (IBD) includes Crohn disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U), and its prevalence is…
1. A University of Calgary study published in Science Advances this month found that chronic wasting disease can spread silently in animals with no clinical symptoms, and demonstrated limited but detectable cross-species prion transmission in nonhuman primate models. 2. There are no confirmed human cases, but the expanding geographic footprint of the disease in wild […] The post Chronic Wasting…
1. In this target trial emulation, same-day administration of COVID-19 and influenza vaccines was not associated with an increased risk of adverse events. 2. No differences in adverse event risk were observed across the bivalent, XBB-adapted, and KP-adapted COVID-19 vaccine formulations. Evidence Rating Level: 2 (Good) Study Rundown: The evolution of SARS-CoV-2 has led to […] The post Concomitant…
1. An Andes virus outbreak aboard the MV Hondius expedition cruise ship led to severe respiratory illness, multiple deaths, and contact tracing across 32 countries. 2. The episode is clinically important because Andes virus is the only hantavirus with documented person-to-person transmission, although it does not behave like a highly transmissible airborne pathogen. The Andes […] The post Cruise…
