1. Among children with inflammatory bowel disease, there were no significant differences in serious or outpatient infection risk between initiating infliximab (Remicade) and adalimumab (Humira). Evidence Rating Level: 2 (Good) Study Rundown: Pediatric Inflammatory Bowel Disease (IBD) includes Crohn disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U), and its prevalence is…
1. A June 2026 NPR investigation found the commercial gut microbiome market has run far ahead of what the science actually supports, with researchers pointing out that there is no agreed-upon definition of a healthy microbiome and that most DTC testing products are not held to diagnostic standards. 2. What the evidence does support is […] The post The Gut Health Supplement Industry Has Outrun the…
1. In this retrospective cohort study, carvedilol was associated with a lower risk of major liver decompensation compared with nadolol and propranolol. 2. Carvedilol was also associated with lower risks of individual decompensation outcomes, including ascites, spontaneous bacterial peritonitis (SBP), and hepatorenal syndrome (HRS). Evidence Rating Level: 2 (Good) Study Rundown: Nonselective…
1. Male sex and Hispanic ethnicity were associated with increased risk of early-onset colorectal cancer (EOCRC). 2. Among females, higher birthweight and older paternal age were associated with increased EOCRC risk. 3. Among males, having a foreign-born mother was associated with lower EOCRC risk. Evidence Rating Level: 3 (Average) EOCRC is defined as CRC diagnosed […] The post Male sex and…
1. In this study, antibiotics were prescribed in nearly all visits for uncomplicated diverticulitis between 2015 and 2025, despite guideline recommendations discouraging routine antibiotic use. 2. Fluoroquinolone-based regimens and amoxicillin-clavulanate were the most commonly prescribed antibiotics, with prescribing patterns shifting toward amoxicillin-clavulanate over time. Evidence Rating…
1. Increased intake of sugar-sweetened beverages was associated with increased risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma, while intake of artificially sweetened beverages was not associated with liver cancer risk overall or by subtype. Evidence Rating Level: 2 (Good) Study Rundown: Liver cancer is among the leading causes of cancer mortality worldwide. Consumption of…
1. High-fidelity adherence to an enhanced recovery protocol was associated with a significantly shorter length of stay and fewer complications compared to low-fidelity care in pediatric patients undergoing elective gastrointestinal surgery. 2. Protocol adherence improved across study phases, and electronic health record order set integration and favorable site culture were the institutional…
1. 1 litre polyethylene glycol with ascorbate (1L-PEG-Asc) showed superior bowel cleansing efficacy compared to 2 litre polyethylene glycol with ascorbate (2L-PEG-Asc) in adult patients undergoing colonoscopy for colorectal cancer (CRC) screening. Evidence Rating Level: 1 (Excellent) Colonoscopy is a highly effective procedure for CRC screening and has been shown to reduce CRC mortality.…
1. Perianal 2% lidocaine gel significantly reduced anal pain and shortened cecal intubation time during unsedated colonoscopy in adults aged 18–40 years. 2. The intervention appeared safe in this small trial and may be especially useful for junior endoscopists, but generalizability is limited by the single-centre design, modest sample size, and exclusion of patients older […] The post Perianal…
1. Robotic component separation for ventral hernia repair was associated with lower postoperative complication rates, shorter length of stay, and fewer readmissions compared to the open approach. Evidence Rating Level: 2 (Good) Surgical repair of complex ventral hernias is challenging and associated with high morbidity. While component separation is commonly used to repair complex ventral […] The…
