1. In patients with estrogen receptor (ER)+ and human epidermal growth factor receptor 2 (HER2)- breast cancer, certain tumour microenvironments (TMEs) were associated with improved breast cancer progression and treatment response to tamoxifen (Nolvadex). Evidence Rating Level: 1 (Excellent) The TME of tumour, immune, and stromal cells varies depending on breast cancer estrogen receptor status.…
1. Active surveillance was cost-effective over 5 years compared with standard surgery in patients with esophageal cancer and complete clinical response after neoadjuvant chemoradiotherapy. Evidence Rating Level: 1 (Excellent) Active surveillance for patients with esophageal cancer and a complete clinical response (CCR) after neoadjuvant chemoradiotherapy (nCRT) is noninferior to standard surgery…
1. Younger age (<59.6 years) and systemic metastases (>1) were independent predictors of survival among patients with choroidal metastases. Evidence Rating Level: 2 (Good) Around 1–2% of all cancer patients develop intraocular metastases, with the choroid representing the primary site of metastatic involvement (90%). It is unclear how age and primary tumor type impact survival […] The post Younger…
1. Among a large cohort of breast cancer survivors, those who participated in digital mental health treatment reported a reduction in symptoms of anxiety, with additional human coaching associated with a reduction in depression. Evidence Rating Level: 1 (Excellent) Almost 50% of all women suffering from advanced breast cancer experience significant anxiety and depression within […] The post A…
1. In a large cohort study, an increased risk of uterine cancer was found in women with enrollment addresses linked to a community water supply with known tap water contamination, with the highest risks associated with trihalomethanes and haloacetic acids exposure, and little to no risk associated with nitrate, arsenic, or uranium levels. Evidence Rating […] The post Contaminated drinking water is…
1. In this phase 1-2 trial involving patients with newly diagnosed acute myeloid leukemia who were ineligible for intensive chemotherapy, an all-oral regimen of decitabine–cedazuridine plus venetoclax was well tolerated without higher-grade toxic effects. 2. In the phase 2b segment, a complete response was achieved in nearly half of patients who received the intervention. Evidence […] The post…
1. The use of enzalutamide (Xtandi) and abiraterone (Zytiga) in metastatic castration-sensitive prostate cancer (mCSPC) was associated with similar overall survival (OS). 2. The use of enzalutamide was associated with an improved OS among patients over the age of 75 years. Evidence Rating Level: 2 (Good) Enzalutamide and abiraterone are two androgen-receptor pathway inhibitors (ARPI) […] The post…
1. Chemotherapy appears to be independently associated with reduced pain severity in advanced pancreatic cancer, reinforcing the importance of routine, longitudinal pain assessment and proactive, individualized symptom management from diagnosis through palliative care. Evidence Rating Level: 2 (Good) Pain is a highly prevalent and debilitating symptom in advanced pancreatic cancer, yet…
1. Although neurological symptoms (motor deficits, sensory impairment) were more frequent in patients with sitting-related sacral pain on univariate comparison, this association did not hold in multivariable analysis (aOR 0.83, 95% CI 0.21–2.95, p=0.780), indicating spinal instability—not neurological compromise—was the primary driver of this pain. 2. Patients with sitting-related sacral pain had…
1. In the management of adult patients with metastatic urothelial carcinoma (MUC), enfortumab vedotin plus pembrolizumab (EV/P) was well-tolerated and significantly more effective than gemcitabine plus cisplatin (G/C). Evidence Rating Level: 2 (Good) Recent clinical trials have demonstrated that EV/P offers greater overall survival (OS) and progression-free survival (PFS) compared with…
